Benzyl 2-[(2-nitrophenyl)formamido]acetate

Base Information

• Chemical Name: Benzyl 2-[(2-nitrophenyl)formamido]acetate
• CAS No.: 150374-96-2
• Molecular Formula: C16H14N2O5
• Molecular Weight: 314.298
• DSSTox Substance ID: DTXSID601256256
• Mol file: 150374-96-2.mol

Synonyms:benzyl 2-[(2-nitrophenyl)formamido]acetate;150374-96-2;Glycine,N-(2-nitrobenzoyl)-,phenylmethyl ester;SCHEMBL7301828;DTXSID601256256;N-(2-Nitrobenzoyl)glycine phenylmethyl ester

Chemical Property of Benzyl 2-[(2-nitrophenyl)formamido]acetate

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 314.09027155
• Heavy Atom Count: 23
• Complexity: 429

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)CNC(=O)C2=CC=CC=C2[N+](=O)[O-]

Technology Process of Benzyl 2-[(2-nitrophenyl)formamido]acetate

There total 2 articles about Benzyl 2-[(2-nitrophenyl)formamido]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycine benzyl ester p-toluenesulfonic acid salt (1738-76-7) + 2-nitrobenzyl chloride (610-14-0) → N-(2-nitrobenzoyl)glycine benzyl ester (150374-96-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 ℃; for 5h;

DOI:10.1016/j.carres.2003.10.020

Reference yield:

ortho-nitrobenzoic acid (552-16-9,104810-18-6) → N-(2-nitrobenzoyl)glycine benzyl ester (150374-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride; N,N-dimethylformamide / tetrahydrofuran / 2 h / 20 °C

2: 3.5 g / triethylamine / tetrahydrofuran / 5 h / 0 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1016/j.carres.2003.10.020

Reference yield: 82.0%

N-(2-nitrobenzoyl)glycine benzyl ester (150374-96-2) → N-(2-nitrobenzoyl)glycinamide (672912-60-6)

Guidance literature:

With ammonium hydroxide; In methanol; at 20 ℃; for 10h;

DOI:10.1016/j.carres.2003.10.020

upstream raw materials:

glycine benzyl ester p-toluenesulfonic acid salt

2-nitrobenzyl chloride

ortho-nitrobenzoic acid

Downstream raw materials:

N-(2-aminobenzoyl)-glycine

N-(2-nitrobenzoyl)glycinamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 150374-96-2 Glycine, N-(2-nitrobenzoyl)-, phenylmethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send