3-(2-Hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propan-1-one

Base Information

Chemical Name:3-(2-Hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propan-1-one
CAS No.:15097-71-9
Molecular Formula:C17H18O4
Molecular Weight:286.328
Hs Code.:
DSSTox Substance ID:DTXSID60707144
Wikidata:Q82640807
Mol file:15097-71-9.mol

Synonyms:15097-71-9;3-(2-Hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propan-1-one;SCHEMBL7193997;DTXSID60707144

Suppliers and Price of 3-(2-Hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-Hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propan-1-one

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:286.12050905
Heavy Atom Count:21
Complexity:323

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(=O)CCC2=C(C=C(C=C2)OC)O

Technology Process of 3-(2-Hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propan-1-one

There total 7 articles about 3-(2-Hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 89840-16-4,41786-38-3
(+/-)-7-methoxy-2-(4-methoxyphenyl)-2H-chromene

: 15097-71-9
3-(2-hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propan-1-one

Guidance literature:: With chloroauric acid; water; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2012.08.117

Reference yield: 46.0%

: 51410-44-7
1-(4-methoxylphenyl)-2-propen-1-ol

: 41046-70-2
2-iodo-5-methoxyphenol

: 15097-71-9
3-(2-hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propan-1-one

Guidance literature:: With t-BuXPhos palladacycle Gen 2; 1-ethyl-2,2,4,4,4-pentakis(dimethylamino)-2λ⁵,4λ⁵-catenadi(phosphazene); at 80 ℃; for 1h; Inert atmosphere;
DOI:10.1055/s-0036-1588075

Reference yield:

: 552-41-0
1-(2-hydroxy-4-methoxyphenyl)ethanone

: 15097-71-9
3-(2-hydroxy-4-methoxyphenyl)-1-(4-methoxyphenyl)propan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; ethanol

2: sodium tetrahydroborate / isopropyl alcohol

3: chloroauric acid; water / dichloromethane / 24 h / 20 °C

With sodium tetrahydroborate; chloroauric acid; water; sodium hydroxide; In ethanol; dichloromethane; water; isopropyl alcohol; 1: |Claisen-Schmidt Condensation;
DOI:10.1016/j.tetlet.2012.08.117