2,3-Dihydro-1H-indene-4-carbonitrile

Base Information

Chemical Name:2,3-Dihydro-1H-indene-4-carbonitrile
CAS No.:15115-63-6
Molecular Formula:C10H9N
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID80574673
Nikkaji Number:J2.296.478J
Wikidata:Q82463807
Mol file:15115-63-6.mol

Synonyms:2,3-Dihydro-1H-indene-4-carbonitrile;15115-63-6;7-indanecarbonitrile;SCHEMBL9455906;DTXSID80574673;WLZ3291;NTLQZJLDVPCONP-UHFFFAOYSA-N;AT17195

Suppliers and Price of 2,3-Dihydro-1H-indene-4-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2,3-Dihydro-1H-indene-4-carbonitrile

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:143.073499291
Heavy Atom Count:11
Complexity:188

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=C(C1)C(=CC=C2)C#N

Technology Process of 2,3-Dihydro-1H-indene-4-carbonitrile

There total 2 articles about 2,3-Dihydro-1H-indene-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 496-11-7
INDANE

: copper(l) cyanide

: 15115-63-6
2,3-dihydro-1H-indene-4-carbonitrile

: 69975-67-3
5-cyanoindane

Guidance literature:: With 3-(trifluoromethyl)quinoline; palladium diacetate; silver fluoride; N-acetylglycine; at 90 ℃; for 18h; Overall yield = 71 %; regioselective reaction;
DOI:10.1021/acscatal.8b04639

Reference yield:

: 330660-35-0
silver cyanide

: 496-11-7
INDANE

: 15115-63-6
2,3-dihydro-1H-indene-4-carbonitrile

: 69975-67-3
5-cyanoindane

Guidance literature:: With 1,1,1,3',3',3'-hexafluoro-propanol; silver(I) acetate; palladium diacetate; 5-chloro-3-nitropyridin-2-ol; at 100 ℃; for 24h; Overall yield = 83%; Overall yield = 23.8 mg; Sealed tube;
DOI:10.1002/chem.201805772

Reference yield:

: 15115-63-6
2,3-dihydro-1H-indene-4-carbonitrile

: 17450-61-2
1-(2,3-dihydro-1H-inden-4-yl)-N-methylmethanamine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2: sodium hydroxide / tetrahydrofuran / 1 h / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; sodium hydroxide; In tetrahydrofuran;
DOI:10.1021/acs.jmedchem.6b00122