Technology Process of Imidazo[4,5-d][1,3]diazepine,
8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,4,7,8-tetrahydro-3-(phenylmeth
yl)-, (8R)-
There total 10 articles about Imidazo[4,5-d][1,3]diazepine,
8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,4,7,8-tetrahydro-3-(phenylmeth
yl)-, (8R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1.3-propanedithiol; triethylamine;
In
methanol;
Ambient temperature;
DOI:10.1021/jo00074a041
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 99 percent / imidazole / dimethylformamide / 96 h / Ambient temperature
2: 98 percent / aq. LiOH / dioxane / 3 h / 5 °C
3: 1.) N-methylmorpholine, isobutyl chloroformate, 2.) ammonia / 1.) THF, -23 deg C, 90 s, 2.) -23 deg C, 2 h
4: 99 percent / p-toluenesulfonyl chloride, pyridine / CH2Cl2 / 96 h / Ambient temperature
5: 93 percent / trifluoroacetic acid / CH2Cl2; H2O / 0.75 h / 0 °C
6: 97 percent / 2 h / Heating
7: 96 percent / 5-Angstroem molecular sieves / acetonitrile / 2 h / Heating
8: 86 percent / 5-Angstroem molecular sieves, trifluoroacetic acid / 3 h / Heating
9: 99 percent / triethylamine, 1,3-propanedithiol / methanol / Ambient temperature
With
4-methyl-morpholine; pyridine; 1H-imidazole; 1.3-propanedithiol; lithium hydroxide; 5A molecular sieve; ammonia; triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid; isobutyl chloroformate;
In
1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00074a041
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 98 percent / aq. LiOH / dioxane / 3 h / 5 °C
2: 1.) N-methylmorpholine, isobutyl chloroformate, 2.) ammonia / 1.) THF, -23 deg C, 90 s, 2.) -23 deg C, 2 h
3: 99 percent / p-toluenesulfonyl chloride, pyridine / CH2Cl2 / 96 h / Ambient temperature
4: 93 percent / trifluoroacetic acid / CH2Cl2; H2O / 0.75 h / 0 °C
5: 97 percent / 2 h / Heating
6: 96 percent / 5-Angstroem molecular sieves / acetonitrile / 2 h / Heating
7: 86 percent / 5-Angstroem molecular sieves, trifluoroacetic acid / 3 h / Heating
8: 99 percent / triethylamine, 1,3-propanedithiol / methanol / Ambient temperature
With
4-methyl-morpholine; pyridine; 1.3-propanedithiol; lithium hydroxide; 5A molecular sieve; ammonia; triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid; isobutyl chloroformate;
In
1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo00074a041
