7-Isoquinolinecarboxylic acid, 5,6,7,8-tetrahydro-8-oxo-, methyl ester

Base Information

Chemical Name:7-Isoquinolinecarboxylic acid, 5,6,7,8-tetrahydro-8-oxo-, methyl ester
CAS No.:151330-02-8
Molecular Formula:C11H11NO3
Molecular Weight:205.21000
Hs Code.:
Mol file:151330-02-8.mol

Synonyms:Methyl 8-oxo-5,6,7,8-tetrahydroisoquinoline-7-carboxylate;methyl 6,7-dihydro-8(5H)-isoquinolinone-7-carboxylate;

Suppliers and Price of 7-Isoquinolinecarboxylic acid, 5,6,7,8-tetrahydro-8-oxo-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl8-oxo-5,6,7,8-tetrahydroisoquinoline-7-carboxylate 97%
1g
$ 474.00

Chemenu
Methyl8-oxo-5,6,7,8-tetrahydroisoquinoline-7-carboxylate 97%
1g
$ 448.00

Total 2 raw suppliers

Chemical Property of 7-Isoquinolinecarboxylic acid, 5,6,7,8-tetrahydro-8-oxo-, methyl ester

Chemical Property:

PSA：56.26000
LogP:0.99970

Purity/Quality:

95%-98% ^*data from raw suppliers

Methyl8-oxo-5,6,7,8-tetrahydroisoquinoline-7-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-Isoquinolinecarboxylic acid, 5,6,7,8-tetrahydro-8-oxo-, methyl ester

There total 3 articles about 7-Isoquinolinecarboxylic acid, 5,6,7,8-tetrahydro-8-oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33402-75-4
4-methylnicotinic acid methyl ester

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 151330-02-8
methyl 6,7-dihydro-8(5H)-isoquinolinone-7-carboxylate

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

4-methylnicotinic acid methyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

acrylic acid methyl ester; With sodium hydrogencarbonate; acetic acid; more than 3 stages;

Reference yield:

: 55314-29-9
4-methylnicotinic acid ethyl ester

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 151330-02-8
methyl 6,7-dihydro-8(5H)-isoquinolinone-7-carboxylate

Guidance literature:: With lithium diisopropyl amide; Multistep reaction; 1.) THF, -78 deg C, 20 min, 2.) THF, 1.5 h;
DOI:10.1021/jm00074a019

Reference yield:

: 3222-50-2
4-methylnicotinic acid

: 151330-02-8
methyl 6,7-dihydro-8(5H)-isoquinolinone-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 0.5 h / -78 °C

With n-butyllithium; potassium carbonate; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;