ETHYL 4-METHYLNICOTINATE

Base Information

• Chemical Name: ETHYL 4-METHYLNICOTINATE
• CAS No.: 55314-29-9
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2933399090
• Mol file: 55314-29-9.mol

Synonyms:ethyl 4-methyl-3-pyridinecarboxylate;3-Pyridinecarboxylic acid,4-Methyl-,ethyl ester;ETHYL 4-METHYLNICOTINATE;4-Methyl-nicotinsaeure-aethylester;4-methylnicotinic acid ethyl ester;4-Methyl-pyridin-carbonsaeure-(3)-ethylester;ethyl 4-methylpyridine-3-carboxylate;

Chemical Property of ETHYL 4-METHYLNICOTINATE

Chemical Property:

• PSA: 39.19000
• LogP: 1.56670
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl4-methylnicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-METHYLNICOTINATE

There total 15 articles about ETHYL 4-METHYLNICOTINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl 1-acetyl-1,4-dihydro-4-methylpyridine-3-carboxylate (350032-40-5) → 4-methylnicotinic acid ethyl ester (55314-29-9)

Guidance literature:

With manganese(IV) oxide; In toluene; for 72h; Heating;

DOI:10.3987/COM-00-9141

Reference yield: 83.0%

3-cyano-4-methylpyridine (5444-01-9) + ethanol (64-17-5) → 4-methylnicotinic acid ethyl ester (55314-29-9)

Guidance literature:

3-cyano-4-methylpyridine; With sulfuric acid; In water; at 130 ℃; for 17h;

ethanol; In water; at 80 ℃; for 4h;

DOI:10.1002/ejoc.201301736

Reference yield: 76.0%

3-ethoxycarbonyl-1-methoxy-4-methylpyridinium methosulphate (94015-12-0) → 4-methylnicotinic acid ethyl ester (55314-29-9)

Guidance literature:

With sodium ethanolate; ethyl 2-sulfanylacetate; In ethanol; for 0.5h; Heating;

upstream raw materials:

4-methylnicotinic acid

ethanol

3,4-Lutidin

4-methylpyridine-3-carboxylic acid hydrochloride

Downstream raw materials:

4-trans-styryl-nicotinic acid ethyl ester

3-pyridinecarboxylic acid,4-methyl-hydrazide

2,5-dihydro-2-phenylpyrazolo<3',4':5,6>thiopyrano<4,3-c>pyridin-6-ium-3-olate

3-amino-4-methylpyridine

Refernces

• 1、 Fishlock, Dan,Orellana, Arturo,Sayyad, Ashik,Shi, Jiaqi. "Alkylidene Dihydropyridines Are Surrogates for Pyridylic Anions in the Conjugate Addition to α,β-Unsaturated Ketones". supporting information. . Retrieved 2021/12/27.
• 2、 -. "Immunopotentiator agents". Page column 21. . Retrieved 2010/02/05.