2-AMino-1-(4-Methoxyphenyl)ethanone hydrobroMide

Base Information

• Chemical Name: 2-AMino-1-(4-Methoxyphenyl)ethanone hydrobroMide
• CAS No.: 151427-05-3
• Molecular Formula: C9H11NO2.BrH
• Molecular Weight: 246.104
• Hs Code.: 2922509090
• Mol file: 151427-05-3.mol

Synonyms:4'-methoxyphenacylammonium bromide;DL-PMMA;4-methoxy-N-methylamphetamine hydrochloride;4-MMA;

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Chemical Property of 2-AMino-1-(4-Methoxyphenyl)ethanone hydrobroMide

Chemical Property:

• PSA: 52.32000
• LogP: 2.49500

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-AMino-1-(4-Methoxyphenyl)ethanone hydrobroMide

There total 3 articles about 2-AMino-1-(4-Methoxyphenyl)ethanone hydrobroMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(4-methoxyphenyl)ethanone (100-06-1) → <2-(4'-methoxyphenyl)-2-oxoethyl>ammonium bromide (151427-05-3)

Guidance literature:

With hexamethylenetetramine; hydrogen bromide; In chloroform; at 50 ℃; for 3h;

DOI:10.3390/molecules21030232

Reference yield:

(4-methoxy-phenacyl)-hexamethylenetetraminium; bromide (7770-25-4) → <2-(4'-methoxyphenyl)-2-oxoethyl>ammonium bromide (151427-05-3)

Guidance literature:

With hydrogen bromide; In methanol; for 72h; Yield given;

Reference yield:

2-Bromo-4'-methoxyacetophenone (2632-13-5) → <2-(4'-methoxyphenyl)-2-oxoethyl>ammonium bromide (151427-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: CHCl₃ / 12 h / 20 °C

2: 1.99 g / aq. HBr / methanol / 120 h / 20 °C

With hydrogen bromide; In methanol; chloroform; 1: Delepine reaction;

DOI:10.1055/s-2006-942390

upstream raw materials:

(4-methoxy-phenacyl)-hexamethylenetetraminium; bromide

2-Bromo-4'-methoxyacetophenone

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

N-(2-(4-methoxyphenyl)-2-oxoethyl)isonicotinamide

N-(4-methoxyphenacyl)-2,6-dimethylisonicotinamide

N-{2′-(4′′-methoxyphenyl)-2′-oxoethyl}-1-tosylpyrrole-2-carboxamide

5-(4′′-methoxyphenyl)-2-(pyrrol-2′-yl)-1,3-oxazole