5-Chloropentan-2-ol

Base Information

• Chemical Name: 5-Chloropentan-2-ol
• CAS No.: 15146-94-8
• Molecular Formula: C5H11ClO
• Molecular Weight: 122.595
• European Community (EC) Number: 825-413-0
• Nikkaji Number: J536.739E
• Mol file: 15146-94-8.mol

Synonyms:5-chloropentan-2-ol;15146-94-8;5-Chloro-2-pentanol;2-Pentanol, 5-chloro-;1-Chlor-4-pentanol;SCHEMBL3515405;AKOS006385270;BS-46604;CS-0210356;FT-0605157;FT-0777949;E84841;EN300-175246;J-502239

Chemical Property of 5-Chloropentan-2-ol

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 122.0498427
• Heavy Atom Count: 7
• Complexity: 39.1

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CCCCl)O

Technology Process of 5-Chloropentan-2-ol

There total 2 articles about 5-Chloropentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloropent-1-ene (928-50-7) → 5-chloro-2-pentanol (15146-94-8) + 5-chloropentan-1-ol (5259-98-3)

Guidance literature:

With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; Product distribution; 1) THF, 25 deg C, 2 h;

DOI:10.1021/jo00333a009

Reference yield:

5-chloropent-1-ene (928-50-7) → 2-methyltetrahydrofuran (96-47-9) + n-Pent-4-enyl alcohol (821-09-0) + 5-chloro-2-pentanol (15146-94-8)

Guidance literature:

With sodium hydroxide; sodium tetrahydroborate; mercury(II) diacetate; Product distribution; 1.) water, THF, 30 min, 2.) water, 10 min, 0 deg C;

DOI:10.1021/jo00318a019

Reference yield: 99.0%

5-chloro-2-pentanol (15146-94-8) + p-toluenesulfonyl chloride (98-59-9) → 5-chloropentan-2-yl 4-methylbenezenesulfonate (85365-50-0)

Guidance literature:

With trimethylamine hydrochloride; triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02117

upstream raw materials:

5-chloropent-1-ene

Downstream raw materials:

2-methyltetrahydrofuran

5-diethylaminopentan-2-ol

2,4-Dimethoxy-6-phenylsulfanylmethyl-benzoic acid 4-chloro-1-methyl-butyl ester

4-Cloro-1-methylbutyl-2,4-bis-(benzyloxy)-6-(5-benzyloxy-1-penten-1-yl)-benzoat

Refernces

• 1、 Brown, Herbert C.,Chen, Jackson C.. "Hydroboration. 57. Hydroboration with 9-Borabicyclononane of Alkenes Containing Representative Functional Groups". . p. 3978 - 3988. Retrieved 2007/10/02.