1-Hydroxy-2-methylpyrrolidine

Base Information

• Chemical Name: 1-Hydroxy-2-methylpyrrolidine
• CAS No.: 151489-27-9
• Molecular Formula: C5H11NO
• Molecular Weight: 101.148
• DSSTox Substance ID: DTXSID30573893
• Nikkaji Number: J1.216.780F
• Mol file: 151489-27-9.mol

Synonyms:1-hydroxy-2-methylpyrrolidine;151489-27-9;2-Methylpyrrolidin-1-ol;SCHEMBL4458592;DTXSID30573893

Chemical Property of 1-Hydroxy-2-methylpyrrolidine

Chemical Property:

• PSA: 23.47000
• LogP: 0.79780
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 101.084063974
• Heavy Atom Count: 7
• Complexity: 65.1

Purity/Quality:

1-hydroxy-2-methyl-Pyrrolidine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCCN1O

Technology Process of 1-Hydroxy-2-methylpyrrolidine

There total 3 articles about 1-Hydroxy-2-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1,4-dibromopentane (626-87-9) → 2-Methyl-1-hydroxypyrrolidine (151489-27-9)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; for 4h; Heating;

DOI:10.1021/jo990417r

Reference yield: 69.0%

1-pyrroline N-oxide (24423-88-9) + methylmagnesium bromide (75-16-1) → 2-Methyl-1-hydroxypyrrolidine (151489-27-9)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 20 ℃;

DOI:10.1016/S0040-4020(01)85751-3

Reference yield:

→ 2-Methyl-1-hydroxypyrrolidine (151489-27-9)

Guidance literature:

aus Hydroxylamin (6i);

DOI:10.1016/S0040-4039(01)86596-5

upstream raw materials:

1-pyrroline N-oxide

methylmagnesium bromide

1,4-dibromopentane

Downstream raw materials:

2-methyl-1-pyrrolidine