4-(3-chloropropoxy)-1H-indole

Base Information

• Chemical Name: 4-(3-chloropropoxy)-1H-indole
• CAS No.: 151720-06-8
• Molecular Formula: C11H12ClNO
• Molecular Weight: 209.675
• DSSTox Substance ID: DTXSID90470718
• Wikidata: Q82298878
• Mol file: 151720-06-8.mol

Synonyms:4-(3-chloropropoxy)-1H-indole;151720-06-8;1-chloro-3-(indol-4-yloxy)propane;3-chloropropyl indol-4-yl ether;4-(3chloropropoxy)indole;4-(3-chloropropoxy)indole;SCHEMBL1545429;DTXSID90470718;FOGIRJDUSOIUGW-UHFFFAOYSA-N;1-(4-indolyloxy)-3-chloropropane;1-chloro-3-(4-indolyloxy)propane;AKOS015965358;1-chloro-3-(lH-indole-4-oxy)propane;1-chloro-3-(1H-indole-4-oxy)propane;1-chloro-3-(1H-indole -4-oxy)propane;1-chloro-3-(1H-indole-4-oxy) propane

Chemical Property of 4-(3-chloropropoxy)-1H-indole

Chemical Property:

• Boiling Point: 384.8±17.0 °C(Predicted)
• PKA: 17.12±0.30(Predicted)
• PSA: 25.02000
• Density: 1.231±0.06 g/cm3(Predicted)
• LogP: 3.17560
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 209.0607417
• Heavy Atom Count: 14
• Complexity: 177

Purity/Quality:

99% ^*data from raw suppliers

4-(3-CHLORO-PROPOXY)-1H-INDOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CN2)C(=C1)OCCCCl

Technology Process of 4-(3-chloropropoxy)-1H-indole

There total 5 articles about 4-(3-chloropropoxy)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1H-indol-4-ol (2380-94-1) + 1.3-chlorobromopropane (109-70-6) → 1-chloro-3-(indol-4-yloxy)propane (151720-06-8)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 1.5h;

Reference yield: 57.0%

1H-indol-4-ol (2380-94-1) + 1-chloro-3-hydroxypropane (627-30-5) → 1-chloro-3-(indol-4-yloxy)propane (151720-06-8)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In dichloromethane;

DOI:10.1016/j.bmcl.2007.07.086

Reference yield: 17.0%

2-(1H-Indol-4-yloxy)-chloroethane (180161-01-7) → 1-chloro-3-(indol-4-yloxy)propane (151720-06-8)

Guidance literature:

upstream raw materials:

1H-indol-4-ol

1-chloro-3-hydroxypropane

1.3-chlorobromopropane

2-(1H-Indol-4-yloxy)-chloroethane

Downstream raw materials:

(4-fluoro-phenyl)-{4-[3-(1H-indol-4-yloxy)-propoxy]-phenyl}-methanone

ethyl 2-{4-[3-(2-phenyl-7-propyl-1H-indol-6-yloxy)propoxy]indol-1-yl}ethanoate

ethyl 2-{4-[3-(3-phenyl-7-propylbenzo[b]furan-6-yloxy)propoxy]indol-1-yl}ethanoate

ethyl 2-{4-[3-(2-phenyl-7-propylbenzo[b]furan-6-yloxy)propoxy]indol-1-yl}ethanoate