Benzoic acid, 3-bromo-2-hydroxy-5-methoxy-, methyl ester

Base Information

• Chemical Name: Benzoic acid, 3-bromo-2-hydroxy-5-methoxy-, methyl ester
• CAS No.: 153355-46-5
• Molecular Formula: C9H9BrO4
• Molecular Weight: 261.072
• DSSTox Substance ID: DTXSID30458055
• Nikkaji Number: J1.623.821J
• Wikidata: Q82281184
• Mol file: 153355-46-5.mol

Synonyms:153355-46-5;Benzoic acid, 3-bromo-2-hydroxy-5-methoxy-, methyl ester;methyl 3-bromo-2-hydroxy-5-methoxybenzoate;SCHEMBL5241500;DTXSID30458055;YZAZPGYTPQKRNO-UHFFFAOYSA-N;2-Hydroxy-3-bromo-5-methoxybenzoic acid methyl ester;3-bromo-2-hydroxy-5-methoxy-benzoic acid methyl ester

Chemical Property of Benzoic acid, 3-bromo-2-hydroxy-5-methoxy-, methyl ester

Chemical Property:

• PSA: 55.76000
• LogP: 1.94990
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 259.96842
• Heavy Atom Count: 14
• Complexity: 209

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C(=C1)Br)O)C(=O)OC

Technology Process of Benzoic acid, 3-bromo-2-hydroxy-5-methoxy-, methyl ester

There total 1 articles about Benzoic acid, 3-bromo-2-hydroxy-5-methoxy-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

methyl 5-methoxy-2-hydroxybenzoate (2905-82-0) → methyl 3-bromo-2-hydroxy-5-methoxybenzoate (153355-46-5)

Guidance literature:

With bromine; In n-heptane; tert-butyl methyl ether; water;

Reference yield:

methyl 3-bromo-2-hydroxy-5-methoxybenzoate (153355-46-5) + methyl iodide (74-88-4) → 3-bromo-2,5-dimethoxy-benzoic acid methyl ester (204849-21-8)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; Heating / reflux;

Reference yield:

methyl 3-bromo-2-hydroxy-5-methoxybenzoate (153355-46-5) → 2,5-dimethoxy-3-bromobenzoic acid (100940-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 1.33 h / 20 °C

With lithium hydroxide monohydrate; caesium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

upstream raw materials:

methyl 5-methoxy-2-hydroxybenzoate

Downstream raw materials:

3-bromo-2,5-dimethoxy-benzoic acid methyl ester

2,5-dimethoxy-3-bromobenzoic acid