L-N-TRIFLUOROACETYLGLUTAMIC ANHYDRIDE

Base Information

• Chemical Name: L-N-TRIFLUOROACETYLGLUTAMIC ANHYDRIDE
• CAS No.: 1535-57-5
• Molecular Formula: C7H6F3NO4
• Molecular Weight: 225.124
• Hs Code.: 2924199090
• Mol file: 1535-57-5.mol

Synonyms:Glutamic anhydride,n-(trifluoroacetyl);N-trifluoroacetyl-L-glutamic acid-anhydride;n-(2,6-dioxotetrahydro-2h-pyran-3-yl)-2,2,2-trifluoroacetamide;L-(trifluoroacetyl)-glutamic anhydride;trifluoroacetyl-L-glutamic anhydride;N-Trifluoroacetylglutamic anhydride;N-Trifluoracetyl-L-glutaminsaeureanhydrid;

Chemical Property of L-N-TRIFLUOROACETYLGLUTAMIC ANHYDRIDE

Chemical Property:

• Vapor Pressure: 4.3E-06mmHg at 25°C
• Boiling Point: 383.7oC at 760 mmHg
• Flash Point: 185.9oC
• PSA: 75.96000
• Density: 1.52g/cm3
• LogP: 0.73740

Purity/Quality:

97% ^*data from raw suppliers

(L)-N-(TRIFLUOROACETYL)GLUTAMIC ACID ANHYDRIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of L-N-TRIFLUOROACETYLGLUTAMIC ANHYDRIDE

There total 3 articles about L-N-TRIFLUOROACETYLGLUTAMIC ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(2,2,2-trifluoroacetyl)-L-glutamic acid (45172-40-5) → (S)-N-(2,6-dioxotetrahydro-2H-pyran-3-yl)-2,2,2-trifluoroacetamide (1535-57-5)

Guidance literature:

With acetic anhydride; at 70 - 80 ℃; Temperature; Inert atmosphere; Large scale;

Reference yield: 55.0%

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + trifluoroacetic anhydride (407-25-0) → (S)-N-(2,6-dioxotetrahydro-2H-pyran-3-yl)-2,2,2-trifluoroacetamide (1535-57-5)

Guidance literature:

DOI:10.1016/S0040-4039(00)88671-2

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → (S)-N-(2,6-dioxotetrahydro-2H-pyran-3-yl)-2,2,2-trifluoroacetamide (1535-57-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / methanol / 20 - 30 °C / Inert atmosphere; Large scale

2: acetic anhydride / 70 - 80 °C / Inert atmosphere; Large scale

With acetic anhydride; triethylamine; In methanol;

upstream raw materials:

L-glutamic acid

trifluoroacetic anhydride

(2,2,2-trifluoroacetyl)-L-glutamic acid

Downstream raw materials:

(S)-5-methoxy-5-oxo-2-(2,2,2-trifluoroacetamido)pentanoic acid

N-Tfa-L-Glu-OMe

N-Tfa-L-Glu-OMe-γ-Dcha Salt

trifluoroacetyl-γ-L-glutamyl-p-cyanoanilide