CHEMBRDG-BB 4010495

Base Information

• Chemical Name: CHEMBRDG-BB 4010495
• CAS No.: 153863-34-4
• Molecular Formula: C10H9FN2O
• Molecular Weight: 192.19000
• Hs Code.: 2933199090
• Mol file: 153863-34-4.mol

Synonyms:

Chemical Property of CHEMBRDG-BB 4010495

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 325.863oC at 760 mmHg
• Flash Point: 150.877oC
• PSA: 38.05000
• Density: 1.263g/cm3
• LogP: 1.50370

Purity/Quality:

97% ^*data from raw suppliers

[1-(4-fluorophenyl)-1H-pyrazol-4-yl]methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CHEMBRDG-BB 4010495

There total 3 articles about CHEMBRDG-BB 4010495 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde (890652-03-6) → [1-(4-fluorophenyl)-1H-pyrazol-4-yl]methanol (153863-34-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/anie.201604149

Reference yield: 96.0%

ethyl 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate (138907-73-0) → [1-(4-fluorophenyl)-1H-pyrazol-4-yl]methanol (153863-34-4)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 7h; Heating;

DOI:10.1002/jhet.5570300427

Reference yield:

4-fluorophenylhydrazine (371-14-2) → [1-(4-fluorophenyl)-1H-pyrazol-4-yl]methanol (153863-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / acetic acid / ethanol / 2 h / Heating

2: 96 percent / LiAlH₄ / diethyl ether / 7 h / Heating

With lithium aluminium tetrahydride; acetic acid; In diethyl ether; ethanol;

DOI:10.1002/jhet.5570300427

upstream raw materials:

ethyl 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

4-fluorophenylhydrazine

1-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde

Downstream raw materials:

4-(bromomethyl)-1-(4-fluorophenyl)-1H-pyrazole

[1-(4-Fluoro-phenyl)-1H-pyrazol-4-yl]-acetonitrile

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