3-(4-CHLOROANILINO)-3-OXOPROPANOIC ACID

Base Information

• Chemical Name: 3-(4-CHLOROANILINO)-3-OXOPROPANOIC ACID
• CAS No.: 15386-78-4
• Molecular Formula: C9H8ClNO3
• Molecular Weight: 213.62
• Mol file: 15386-78-4.mol

Synonyms:

Chemical Property of 3-(4-CHLOROANILINO)-3-OXOPROPANOIC ACID

Chemical Property:

• Melting Point: 168 °C (decomp)
• Boiling Point: 479.3±30.0 °C(Predicted)
• PKA: -0.45±0.32(Predicted)
• PSA: 66.40000
• Density: 1.467±0.06 g/cm3(Predicted)
• LogP: 1.82620

Purity/Quality:

99% ^*data from raw suppliers

3-(4-Chloroanilino)-3-oxopropanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-CHLOROANILINO)-3-OXOPROPANOIC ACID

There total 6 articles about 3-(4-CHLOROANILINO)-3-OXOPROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C10H10ClNO3 (106109-63-1) → N-(4-chlorophenyl)malonamic acid (15386-78-4)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In water; at 20 ℃; for 1h;

DOI:10.1021/jm401073p

Reference yield: 75.0%

cycl-isopropylidene malonate (2033-24-1) + 4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)malonamic acid (15386-78-4)

Guidance literature:

In neat (no solvent); at 60 ℃; for 4h;

DOI:10.1016/j.tetlet.2020.151778

Reference yield:

ethyl 3-(4-chloroanilino)-3-oxopropionate (15386-84-2) → N-(4-chlorophenyl)malonamic acid (15386-78-4)

Guidance literature:

Verseifung;

upstream raw materials:

ethyl 3-(4-chloroanilino)-3-oxopropionate

malonic acid

4-chloro-aniline

C₁₀H₁₀ClNO₃

Downstream raw materials:

N-(4-chlorophenyl)acetamide

6-chloro-4-hydroxyquinolin-2(1H)-one

N-(4-chloro-phenyl)-2-(2-methoxy-benzylidene)-malonamic acid

2-methoxy-trans-cinnamic acid-(4-chloro-anilide)