15386-84-2

Upstream product

• 106-47-8 4-chloro-aniline 
• 105-53-3 diethyl malonate 
• 1071-46-1 hydrogen ethyl malonate 
• 6148-64-7 ethyl potassium malonate 
• 108-20-3 di-isopropyl ether 
• 55552-69-7 2-ethylmalonyl dichloride 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 2592-95-2 benzotriazol-1-ol 
• 104-12-1 p-chlorphenylisocyanate 
• 108343-17-5 2,2-Dimethyl-aziridine-1-carboxylic acid (4-chloro-phenyl)-amide 
• 14212-60-3 3.3-Diethyl-acrylsaeure-<4-chlor-anilid> 

Downstream Products

• 15386-78-4 N-(4-chlorophenyl)malonamic acid 
• 65050-99-9 N-(4-Chlorphenyl)carbamoyl-acetohydroxamsaeure 
• 70793-52-1 Malonsaeure-<4-chlor-anilid>-hydrazid 
• 913819-72-4 ethyl 1-(4-chlorophenyl)-5-hydroxy-4,5-dimethyl-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate 
• 79622-26-7 2-(4-Chloro-phenylcarbamoyl)-3,3-bis-methylsulfanyl-acrylic acid ethyl ester 
• 79613-14-2 1,3-Dithiolan-2-yliden-p-chloracetanilid 
• 79613-15-3 N-(4-Chloro-phenyl)-2-[1,3]dithiolan-2-ylidene-malonamic acid 
• 79613-07-3 3,3-Dichloro-2-(4-chloro-phenylcarbamoyl)-acrylic acid ethyl ester 
• 79612-98-9 2-Ethoxycarbonyl-2-(4-chlorphenyl-carbamoyl)-dithioessigsaeuremethylester 
• 79613-05-1 Imidazolidin-2-yliden-malonsaeureethylester-p-chloranilid 
• 79612-88-7 N-(4-Chloro-phenyl)-2-[1,3]dithiolan-2-ylidene-malonamic acid ethyl ester 
• 79612-95-6 N-(4-Chloro-phenyl)-2-[1,3]dithian-2-ylidene-malonamic acid ethyl ester 
• 79612-85-4 2-(4-Chloro-phenylcarbamoyl)-3,3-bis-ethylsulfanyl-acrylic acid ethyl ester 
• 79613-06-2 2,3-Dihydrobenzthiazol-2-yliden-malonsaeureethylester-p-chloranilid 

Relevant academic research and scientific papers

AlCl 3 -Mediated Synthesis of 4-Aryl-2-quinolone-3-carboxylates

4-Aryl-2-quinolones are important skeletons from both chemical and medicinal viewpoints. We herein report the development of an efficient synthetic method for 3-substituted 4-aryl-2-quinolones. The key reaction in this process involves an AlCl 3/sub

LIGANDS FOR THE MODULATION OF ECDYSONE RECEPTORS AND CONTROL OF INSECT GROWTH

The present invention relates to the use of N-substituted γ-methylene γ-lactams as non-steroidal ligands for modulating ecdysone receptors generally and, in particular, ecdysone receptors of the Australian blowfly, Lucilia cuprina. The present invention f

INHIBITION OF INVERTEBRATES USING LIGANDS THAT MODULATE ECDYSONE RECEPTORS

The present invention relates to the use of N-substituted γ-methylene γ-lactams as non- steroidal ligands for modulating ecdysone receptors generally (resulting in controlled insect growth) and, in particular, ecdysone receptors of the Australian blowfly,

Diamine derivatives

A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4??(1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

Synthesis of N-substituted γ-methylene γ-lactams

N-Substituted cyanoacetamides 1 were condensed with 1,2-diketones 2 under base catalysis to form ?-hydroxy ?-lactams 3. Treatment of 3 with acids gave novel fungicidal ?-methylene ?-lactams 4. The exocyclic double bond of 4b reacted reversibly with 4-toluene sulfinate. CSIRO 2005.

DIAMINE DERIVATIVES

A compound represented by the general formula (1):Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4 wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE

There are provided novel compounds of formula (I) wherein R?1?, R?4?, R?5?, G?1?, G?2?, X, L, Y?1?, Y?2? and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.

Use of malonic acid derivative compounds for retarding plant growth

This invention relates to a method for retarding plant growth by applying to the plant an effective amount of a malonic acid derivative compound. This invention also relates to novel malonic acid derivative compounds and processes for the preparation thereof.

Reactions with Aziridines, 42. - The Regioselectivity of the Ring Opening of Activated 2,2-Dimethylaziridines by Carbanions of the β-Dicarbonyl Type. Influence of the Size of the Nucleophile

The aziridine ring of the 1-acyl-2,2-dimethylaziridines 1a-c is cleaved abnormally (between N and CMe2) by the substituted ethyl cyanoacetates 3M, P (M = methyl, P = phenyl) in ethanolic ethoxide solution, while the ring is not cleaved by diethyl malonate