2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]-, (5Z)-

Base Information

Chemical Name:2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]-, (5Z)-
CAS No.:154052-92-3
Molecular Formula:C10H7NO3S
Molecular Weight:
Hs Code.:
Mol file:154052-92-3.mol

Synonyms:

Suppliers and Price of 2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]-, (5Z)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 7 raw suppliers

Chemical Property of 2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]-, (5Z)-

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

General Description 2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]-, (5Z)- (also known as 5-(4-hydroxybenzylidene)thiazolidine-2,4-dione) is a derivative of thiazolidinedione (TZD) that exhibits notable biological activity, particularly as an inhibitor of mitochondrial pyruvate carrier (MPC). Studies have shown that 2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]-, (5Z)-, along with its analogs, significantly inhibits mitochondrial respiration, with comparable efficacy to the potent MPC inhibitor UK5099. It demonstrates minimal impact on non-coupled respiration and weak effects on alternative mitochondrial substrate pathways. Additionally, it has been observed to improve survival and lifespan in *Drosophila melanogaster*, reversing the detrimental effects of a high-fat diet and suggesting potential metabolic modulation through MPC inhibition. 2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]-, (5Z)-'s structural features, including the 4-hydroxybenzylidene moiety, contribute to its bioactivity and electronic properties, as evidenced by theoretical and experimental NMR studies.

Technology Process of 2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]-, (5Z)-

There total 9 articles about 2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]-, (5Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.37%