(2R,4R)-2-[(Benzyloxy)methyl]-1,3-dioxolane-4-carboxylic acid

Base Information

Chemical Name:(2R,4R)-2-[(Benzyloxy)methyl]-1,3-dioxolane-4-carboxylic acid
CAS No.:154459-76-4
Molecular Formula:C₁₂H₁₄O₅
Molecular Weight:238.24
Hs Code.:
DSSTox Substance ID:DTXSID90562122
Wikidata:Q82446137
Mol file:154459-76-4.mol

Synonyms:154459-76-4;DTXSID90562122;(2R,4R)-2-[(Benzyloxy)methyl]-1,3-dioxolane-4-carboxylic acid

Suppliers and Price of (2R,4R)-2-[(Benzyloxy)methyl]-1,3-dioxolane-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (2R,4R)-2-[(Benzyloxy)methyl]-1,3-dioxolane-4-carboxylic acid

Chemical Property:

XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:238.08412354
Heavy Atom Count:17
Complexity:249

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OC(O1)COCC2=CC=CC=C2)C(=O)O
Isomeric SMILES:C1[C@@H](O[C@@H](O1)COCC2=CC=CC=C2)C(=O)O

Technology Process of (2R,4R)-2-[(Benzyloxy)methyl]-1,3-dioxolane-4-carboxylic acid

There total 2 articles about (2R,4R)-2-[(Benzyloxy)methyl]-1,3-dioxolane-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288162-71-0
(R)-2-Benzyloxymethyl-[1,3]dioxolane-4-carboxylic acid methyl ester

: 154459-76-4
(2R,4R)-2-Benzyloxymethyl-[1,3]dioxolane-4-carboxylic acid

: 655245-80-0
(2S,4R)-2-Benzyloxymethyl-[1,3]dioxolane-4-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2003.09.008

Reference yield:

: 154371-93-4
(1S,2S)-1,2-Bis-((R)-2-benzyloxymethyl-[1,3]dioxolan-4-yl)-ethane-1,2-diol

: 154459-76-4
(2R,4R)-2-Benzyloxymethyl-[1,3]dioxolane-4-carboxylic acid

: 655245-80-0
(2S,4R)-2-Benzyloxymethyl-[1,3]dioxolane-4-carboxylic acid

Guidance literature:: With ruthenium trichloride; sodium hypochlorite; In water; acetonitrile; Yield given. Yields of byproduct given;
DOI:10.1016/S0957-4166(00)80092-0

Reference yield:

: 154459-76-4
(2R,4R)-2-Benzyloxymethyl-[1,3]dioxolane-4-carboxylic acid

: 501013-38-3
7-(2-benzyloxymethyl-[1,3]dioxolan-4-yl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / acetonitrile

2: bromotrimethylsilane / CH₂Cl₂ / 0.75 h / 0 - 20 °C

3: tris-[2-(2-methoxyethoxy)ethyl]amine; KOH / acetonitrile / 0.5 h

With pyridine; potassium hydroxide; trimethylsilyl bromide; Tris(3,6-dioxaheptyl)amine; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2003.09.008