4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic acid

Base Information

Chemical Name:4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic acid
CAS No.:15448-77-8
Molecular Formula:C10H14O4
Molecular Weight:198.219
Hs Code.:2917200090
European Community (EC) Number:835-110-5
Mol file:15448-77-8.mol

Synonyms:4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic acid;15448-77-8;4-methoxycarbonylbicyclo[2.2.1]heptane-1-carboxylic acid;MFCD20638750;4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylicacid;Bicyclo[2.2.1]heptane-1,4-dicarboxylic acid, monomethyl ester;SCHEMBL1536077;SCHEMBL16875558;KVIKABYOBCHKNX-UHFFFAOYSA-N;AKOS022645828;SB15501;AS-51499;SY120854;CS-0029892;EN300-178310;P12806;A900971;Z1262512961

Suppliers and Price of 4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylicAcid
500mg
$ 795.00

SynQuest Laboratories
4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic acid
1 g
$ 1492.00

SynQuest Laboratories
4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic acid
250 mg
$ 692.00

Crysdot
4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylicacid 95+%
1g
$ 626.00

Chemenu
4-methoxycarbonylbicyclo[2.2.1]heptane-1-carboxylicacid 97%
50g
$ 4900.00

American Custom Chemicals Corporation
4-(METHOXYCARBONYL)BICYCLO[2.2.1]HEPTANE-1-CARBOXYLIC ACID 95.00%
5MG
$ 496.62

AK Scientific
4-(METHOXYCARBONYL)BICYCLO[2.2.1]HEPTANE-1-CARBOXYLICACID
250mg
$ 453.20

Total 13 raw suppliers

Chemical Property of 4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic acid

Chemical Property:

Melting Point:105-107 °C
Boiling Point:305.7±25.0 °C(Predicted)
PKA:4.50±0.10(Predicted)
PSA：66.43000
Density:1.370±0.06 g/cm3(Predicted)
LogP:-0.14020
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:198.08920892
Heavy Atom Count:14
Complexity:287

Purity/Quality:

97% ^*data from raw suppliers

4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C12CCC(C1)(CC2)C(=O)O
Uses 4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic Acid (CAS# 15448-77-8) is a reagent having SIRT6 activating effect, and is used for treating peripheral inflammatory disease.

Technology Process of 4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic acid

There total 8 articles about 4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

: 15448-76-7
dimethyl bicyclo<2.2.1>heptane-1,4-dicarboxylate

: 15448-77-8
4-carbomethoxybicyclo<2.2.1>heptane-1-carboxylic acid

Guidance literature:: With lipaze PS-30 from Burkholderia cepacia; In aq. phosphate buffer; at 40 ℃; for 65h; pH=7; Concentration; pH-value; Reagent/catalyst; Temperature; Time; Enzymatic reaction;
DOI:10.1021/op400254c

Reference yield: 88.7%

: 15448-76-7
dimethyl bicyclo<2.2.1>heptane-1,4-dicarboxylate

: 15544-51-1
bicyclo<2.2.1>heptane-1,4-dicarboxylic acid

: 15448-77-8
4-carbomethoxybicyclo<2.2.1>heptane-1-carboxylic acid

Guidance literature:: With Novozym 435 from Candida antarctica; In aq. phosphate buffer; for 24h; pH=4.81; Concentration; pH-value; Solvent; Enzymatic reaction;
DOI:10.1021/op400254c

Reference yield:

: 2435-36-1
cyclopentane?1,3?dimethyl formate

: 15448-77-8
4-carbomethoxybicyclo<2.2.1>heptane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 - 0 °C

1.2: 12 h / 20 °C

2.1: methanol; sodium hydroxide / tetrahydrofuran / 0 - 20 °C

With methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; hexane;