AKOS 212-44

Base Information

• Chemical Name: AKOS 212-44
• CAS No.: 4087-80-3
• Molecular Formula: C₁₁H₁₂O₅
• Molecular Weight: 224.213
• Hs Code.: 2932209090
• Mol file: 4087-80-3.mol

Synonyms:Phthalide,4,5,6-trimethoxy- (6CI,7CI,8CI); 4,5,6-Trimethoxyphthalide; NSC 26223

Chemical Property of AKOS 212-44

Chemical Property:

• Vapor Pressure: 0.00255mmHg at 25°C
• Melting Point: 134.7-135.7 °C
• Boiling Point: 287°C at 760 mmHg
• Flash Point: 122.9°C
• PSA: 53.99000
• Density: 1.259g/cm³
• LogP: 1.38280

Purity/Quality:

99% ^*data from raw suppliers

4,5,6-Trimethoxy-2-benzofuran-1(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS 212-44

There total 15 articles about AKOS 212-44 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

dimethyl sulfoxide (67-68-5,8070-53-9) + Eudesmic acid (118-41-2) → 4,5,6-trimethoxyphthalide (4087-80-3)

Guidance literature:

With ammonium persulfate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In chlorobenzene; at 110 ℃; for 12h; Inert atmosphere;

DOI:10.1002/chem.201600865

Reference yield:

→ 4,5,6-trimethoxyphthalide (4087-80-3)

Guidance literature:

at 180 - 200 ℃;

Reference yield:

4-iodo-5,6-dimethoxy-phthalide (855661-46-0) → 4,5,6-trimethoxyphthalide (4087-80-3)

Guidance literature:

With potassium hydroxide; copper;

DOI:10.1021/jo01374a014

upstream raw materials:

4-iodo-5,6-dimethoxy-phthalide

7-iodo-4,5,6-trimethoxy-phthalide

3-acetyl-4,5,6-trimethoxy-phthalide

5,6,7-trimethoxy-3-oxo-phthalan-1-carboxylic acid

Downstream raw materials:

7-(chloromethyl)-4,5,6-trimethoxyisobenzofuran-1(3H)-one

6-(α-hydroxy-isopropyl)-2,3,4-trimethoxy-benzyl alcohol

4-hydroxy-3,5-dimethoxyphthalide

2-formyl-3,4,5-trimethoxybenzoic acid

Refernces