6,7-Dimethoxy-1-(4-methoxyphenyl)-3,4-dihydroisoquinoline

Base Information

Chemical Name:6,7-Dimethoxy-1-(4-methoxyphenyl)-3,4-dihydroisoquinoline
CAS No.:15462-83-6
Molecular Formula:C18H19NO3
Molecular Weight:297.354
Hs Code.:2933499090
DSSTox Substance ID:DTXSID10357951
Nikkaji Number:J875.277J
Wikidata:Q82138158
ChEMBL ID:CHEMBL1569152
Mol file:15462-83-6.mol

Synonyms:6,7-dimethoxy-1-(4-methoxyphenyl)-3,4-dihydroisoquinoline;15462-83-6;Cambridge id 5609408;Oprea1_036265;MLS000583405;CHEMBL1569152;DTXSID10357951;HMS2513P24;HMS3377M22;STL564999;AKOS030496325;SMR000186473;FT-0735311;AB00090384-01;SR-01000214752;J-009124;SR-01000214752-1

Suppliers and Price of 6,7-Dimethoxy-1-(4-methoxyphenyl)-3,4-dihydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
6,7-DIMETHOXY-1-(4-METHOXYPHENYL)-3,4-DIHYDROISOQUINOLINE 95.00%
5MG
$ 505.64

Total 3 raw suppliers

Chemical Property of 6,7-Dimethoxy-1-(4-methoxyphenyl)-3,4-dihydroisoquinoline

Chemical Property:

Vapor Pressure:3.56E-07mmHg at 25°C
Boiling Point:429.3oC at 760 mmHg
Flash Point:171.9oC
PSA：40.05000
Density:1.15g/cm3
LogP:2.54150
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:297.13649347
Heavy Atom Count:22
Complexity:390

Purity/Quality:

98%Min ^*data from raw suppliers

6,7-DIMETHOXY-1-(4-METHOXYPHENYL)-3,4-DIHYDROISOQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=NCCC3=CC(=C(C=C32)OC)OC

Technology Process of 6,7-Dimethoxy-1-(4-methoxyphenyl)-3,4-dihydroisoquinoline

There total 11 articles about 6,7-Dimethoxy-1-(4-methoxyphenyl)-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 15547-66-7
N-(2-<3,4-dimethoxyphenyl>-ethyl)-p-methoxybenzamide

: 15462-83-6
6,7-dimethoxy-1-<(para-methoxy)phenyl>-3,4-dihydroisoquinoline

Guidance literature:: With 2-chloropyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -78 - 45 ℃;
DOI:10.1021/ol9017529

Reference yield: 75.0%

: 55580-65-9
6,7-dimethoxy-1-(4'-methoxyphenyl)-1,2,3,4-tetrahydrioisoquinoline

: 15462-83-6
6,7-dimethoxy-1-<(para-methoxy)phenyl>-3,4-dihydroisoquinoline

Guidance literature:: With cerium(III) chloride; 2-iodoxybenzoic acid; In acetonitrile; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1002/ejoc.201601419

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 15462-83-6
6,7-dimethoxy-1-<(para-methoxy)phenyl>-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / CH₂Cl₂ / 8 h / 20 °C

2: 85 percent / phosphorous oxychloride / toluene / 1 h / 110 °C

With potassium carbonate; trichlorophosphate; In dichloromethane; toluene;
DOI:10.1016/S0968-0896(03)00117-2