6,7-DIMETHOXY-1-(4-METHOXY-PHENYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

Base Information

• Chemical Name: 6,7-DIMETHOXY-1-(4-METHOXY-PHENYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
• CAS No.: 55580-65-9
• Molecular Formula: C18H21NO3
• Molecular Weight: 299.37
• Mol file: 55580-65-9.mol

Synonyms:

Chemical Property of 6,7-DIMETHOXY-1-(4-METHOXY-PHENYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

NLT 98% ^*data from raw suppliers

6,7-Dimethoxy-1-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,7-DIMETHOXY-1-(4-METHOXY-PHENYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

There total 8 articles about 6,7-DIMETHOXY-1-(4-METHOXY-PHENYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-methoxy-benzaldehyde (123-11-5) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 6,7-dimethoxy-1-(4'-methoxyphenyl)-1,2,3,4-tetrahydrioisoquinoline (55580-65-9)

Guidance literature:

4-methoxy-benzaldehyde; 2-(3,4-dimethoxyphenyl)-ethylamine; With trifluoroacetic acid; In toluene; at 140 ℃; for 0.5h; Microwave irradiation;

With sodium hydroxide; In water; pH=8; Cooling;

DOI:10.1021/jo100980p

Reference yield:

N-(4-methoxybenzylidene)-2-(3',4'-dimethoxyphenyl)ethylamine (66040-50-4) → 6,7-dimethoxy-1-(4'-methoxyphenyl)-1,2,3,4-tetrahydrioisoquinoline (55580-65-9)

Guidance literature:

With trifluoroacetic acid; Heating;

DOI:10.1016/j.bmcl.2006.01.042

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 6,7-dimethoxy-1-(4'-methoxyphenyl)-1,2,3,4-tetrahydrioisoquinoline (55580-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: trifluoroacetic acid / Heating

With trifluoroacetic acid; In toluene;

DOI:10.1016/j.bmcl.2006.01.042

upstream raw materials:

2-(p-methoxyphenyl)-4,4-dimethyloxazolidine

2-(3,4-dimethoxyphenyl)-ethylamine

4-methoxy-benzaldehyde

N-(4-methoxybenzylidene)-2-(3',4'-dimethoxyphenyl)ethylamine

Downstream raw materials:

N-acetyl-6,7-dimethoxy-1-(4'-methoxyphenyl)-1,2,3,4-tetrahydrioisoquinoline

6,7-dimethoxy-1-<(para-methoxy)phenyl>-3,4-dihydroisoquinoline

6,7-dimethoxy-1-(4-methoxy-phenyl)-isoquinoline

C₂₅H₂₆FNO₃

Refernces

• 1、 Awuah, Emelia,Capretta, Alfredo. "Strategies and synthetic methods directed toward the preparation of libraries of substituted isoquinolines". supporting information; experimental part. p. 5627 - 5634. Retrieved 2010/11/03.
• 2、 Gitto, Rosaria,De Luca, Laura,Ferro, Stefania,Agnello, Stefano,Russo, Emilio,De Sarro, Giovanbattista,Chimirri, Alba. "Synthesis and structure - Active relationship of 1-aryl-6,7-dimethoxy-1,2, 3,4-tetrahydroisoquinoline anticonvulsants". experimental part. p. 1602 - 1605. Retrieved 2011/02/22.