Urea, N-(3-aminophenyl)-N'-[1-(3,3-dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5- (2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-, (R)-

Base Information

Chemical Name:Urea, N-(3-aminophenyl)-N'-[1-(3,3-dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5- (2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-, (R)-
CAS No.:155412-88-7
Molecular Formula:C27H28N6O3
Molecular Weight:484.558
Hs Code.:
Mol file:155412-88-7.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Urea, N-(3-aminophenyl)-N'-[1-(3,3-dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5- (2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-, (R)-

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
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Technology Process of Urea, N-(3-aminophenyl)-N'-[1-(3,3-dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5- (2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-, (R)-

There total 9 articles about Urea, N-(3-aminophenyl)-N'-[1-(3,3-dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5- (2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42471-56-7
2-(2-aminobenzoyl)pyridine

: 155412-88-7
N-((3R)-1-tert-Butylcarbonylmethyl-2,3-dihydro-2-oxo-5-(pyridin-2-yl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-aminophenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / EDC, DMAP / CH₂Cl₂ / 0.33 h / 0 - 20 °C

2: sat. NH₃ in MeOH / 1 h / Ambient temperature

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 1 h

4: 93 percent / gas. HBr / CH₂Cl₂ / 4 h / 0 °C

6: 1.) diphenyl phosphoazidate, Et₃N / 1.) toluene, a) RT, 2 h, b) reflux, 3 h, 2.) toluene, RT, overnight

7: TFA / CH₂Cl₂ / 0.5 h / Ambient temperature

With dmap; diphenyl phosphoryl azide; ammonia; hydrogen bromide; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm960669+

Reference yield:

: (3-{3-[(R)-1-(3,3-Dimethyl-2-oxo-butyl)-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-ureido}-phenyl)-carbamic acid tert-butyl ester

: 155412-88-7
N-((3R)-1-tert-Butylcarbonylmethyl-2,3-dihydro-2-oxo-5-(pyridin-2-yl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-aminophenyl)urea

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1021/jm960669+

Reference yield:

: 99-05-8,159139-79-4
meta-aminobenzoic acid

: 155412-88-7
N-((3R)-1-tert-Butylcarbonylmethyl-2,3-dihydro-2-oxo-5-(pyridin-2-yl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-aminophenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / 2M aq. KOH / dioxane / Ambient temperature

2: 1.) diphenyl phosphoazidate, Et₃N / 1.) toluene, a) RT, 2 h, b) reflux, 3 h, 2.) toluene, RT, overnight

3: TFA / CH₂Cl₂ / 0.5 h / Ambient temperature

With potassium hydroxide; diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm960669+