1,1-Dipropyl-3-phenylurea

Base Information

• Chemical Name: 1,1-Dipropyl-3-phenylurea
• CAS No.: 15545-56-9
• Molecular Formula: C13H20N2O
• Molecular Weight: 220.315
• Hs Code.: 2924299090
• Mol file: 15545-56-9.mol

Synonyms:Urea,3-phenyl-1,1-dipropyl;1-phenyl-3,3-dipropylurea;1,1-Dipropyl-3-phenylurea;Urea,N'-phenyl-N,N-dipropyl;

Chemical Property of 1,1-Dipropyl-3-phenylurea

Chemical Property:

• PSA: 35.83000
• LogP: 3.35410

Purity/Quality:

1,1-DIPROPYL-3-PHENYLUREA Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1-Dipropyl-3-phenylurea

There total 18 articles about 1,1-Dipropyl-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

(C5H5)2Y[η2:η1-NC5H4NC(O)N(Ph)C(O)NHPh)]*THF (1207295-07-5) → 2C5H5(1-)*Y(3+)*OC(NHC6H5)NC5H4N(1-)=(C5H5)2Y(OC(NHC6H5)NC5H4N) + N-phenyl-N',N'-di(n-propyl)urea (15545-56-9)

Guidance literature:

With n-Pr₂NH; In tetrahydrofuran; under N2; n-Pr2NH (excess) added to THF soln. of Y complex in THF at room temp.; stirred overnight; solvent removed under reduced pressure; solid extd. with n-hexane; residual solid washed with n-hexane; dried; elem. anal.;

DOI:10.1039/b918181d

Reference yield: 94.0%

allyl N-phenylcarbamate (18992-89-7) + di-n-propylamine (142-84-7) → N-phenyl-N',N'-di(n-propyl)urea (15545-56-9)

Guidance literature:

With calcium iodide; In toluene; at 80 ℃; for 12h;

DOI:10.1039/c9nj03111a

Reference yield: 92.0%

tert-butyl phenylcarbamate (3422-01-3) + di-n-propylamine (142-84-7) → N-phenyl-N',N'-di(n-propyl)urea (15545-56-9)

Guidance literature:

di-n-propylamine; With bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct; In toluene; at 40 ℃; for 0.333333h;

tert-butyl phenylcarbamate; In toluene; at 90 ℃; for 2h;

DOI:10.1016/j.tet.2018.06.011

upstream raw materials:

phenyl isocyanate

di-n-propylamine

1-(2-Benzothiazolyl)-4-phenylsemicarbazide

Tris(di-n-propylamino)phosphine

Downstream raw materials:

aniline

di-n-propylamine

N-Phenyl-N'N'-dipropyl-formamidin

Refernces

• 1、 Li, Jian,He, Wang,Lei, Pan,Song, Jiacheng,Huo, Jiyou,Wei, Hongbo,Bai, Hongjin,Xie, Weiqing. "2,2,2-Trifluroenthanol promoted synthesis of unsymmetrical ureas from dioxazolones and amines via tandem lossen rearrangement/condensation process". supporting information. p. 3590 - 3600. Retrieved 2021/10/07.
• 2、 Bui, Tien Tan,Kim, Hee-Kwon. "Lanthanum(III) Trifluoromethanesulfonate Catalyzed Direct Synthesis of Ureas from N-Benzyloxycarbonyl-, N -Allyloxycarbonyl-, and N -2,2,2-Trichloroethoxycarbonyl-Protected Amines". supporting information. p. 997 - 1002. Retrieved 2020/06/17.