Norpropranolol, (+)-

Base Information

Chemical Name:Norpropranolol, (+)-
CAS No.:88547-39-1
Molecular Formula:C13H15 N O2
Molecular Weight:217.268
Hs Code.:
UNII:OTG4IE9L90
DSSTox Substance ID:DTXSID101255027
Nikkaji Number:J581.998I
Wikidata:Q27285837

Synonyms:Norpropranolol, (+)-;UNII-OTG4IE9L90;OTG4IE9L90;88547-39-1;R(+)-1-Amino-3-(1-naphthyloxy)-2-propanol;(+)-norpropranolol;SCHEMBL9777869;DTXSID101255027;(R)-(+)-NDP;(R)-N-DESISOPROPYLPROPRANOLOL;(2R)-1-Amino-3-(1-naphthalenyloxy)-2-propanol;Q27285837;2-Propanol, 1-amino-3-(1-naphthalenyloxy)-, (2R)-;(2R)-(+)-1-(1-NAPHTHYLOXY)-3-AMINO-2-PROPANOL

Suppliers and Price of Norpropranolol, (+)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of Norpropranolol, (+)-

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:217.110278721
Heavy Atom Count:16
Complexity:210

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=CC=C2OCC(CN)O
Isomeric SMILES:C1=CC=C2C(=C1)C=CC=C2OC[C@@H](CN)O

Technology Process of Norpropranolol, (+)-

There total 7 articles about Norpropranolol, (+)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 104730-52-1,104760-42-1,123356-15-0
Acetic acid (S)-1-cyano-2-(naphthalen-1-yloxy)-ethyl ester

: 20862-11-7,30200-48-7,88547-38-0,88547-39-1
(S)-1-Amino-3-(naphthalen-1-yloxy)-propan-2-ol

Guidance literature:: With lithium aluminium tetrahydride;
DOI:10.1016/S0040-4039(01)80880-7

Reference yield:

: 90-15-3
α-naphthol

: 20862-11-7,30200-48-7,88547-38-0,88547-39-1
(S)-1-Amino-3-(naphthalen-1-yloxy)-propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / K₂CO₃ / dimethylformamide / 10 h / 100 °C

2: HCl-AcOH

3: TBAB

4: 79.4 percent / lipase (Pseudomonas sp.) / 24 h / 40 °C / pH 5

5: 81 percent / LAH

With hydrogenchloride; lithium aluminium tetrahydride; potassium carbonate; acetic acid; lipase (Pseudomonas sp.); tetrabutylammomium bromide; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)80880-7

Reference yield:

: 80789-61-3
2-(1-naphthoxy)acetaldehyde diethyl acetal

: 20862-11-7,30200-48-7,88547-38-0,88547-39-1
(S)-1-Amino-3-(naphthalen-1-yloxy)-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: HCl-AcOH

2: TBAB

3: 79.4 percent / lipase (Pseudomonas sp.) / 24 h / 40 °C / pH 5

4: 81 percent / LAH

With hydrogenchloride; lithium aluminium tetrahydride; acetic acid; lipase (Pseudomonas sp.); tetrabutylammomium bromide;
DOI:10.1016/S0040-4039(01)80880-7