4-(tert-Butoxycarbonyloxy)benzylalcohol

Base Information

• Chemical Name: 4-(tert-Butoxycarbonyloxy)benzylalcohol
• CAS No.: 156281-11-7
• Molecular Formula: C12H16O4
• Molecular Weight: 224.257
• Mol file: 156281-11-7.mol

Synonyms:Carbonic acid 1,1-Dimethylethyl 4-(Hydroxymethyl)phenyl Ester;tert-Butyl p-(Hydroxymethyl)phenyl Carbonate;4-(TERT-BUTOXYCARBONYLOXY)BENZYLALCOHOL;tert-butyl 4-(hydroxymethyl)phenyl carbonate;

Chemical Property of 4-(tert-Butoxycarbonyloxy)benzylalcohol

Chemical Property:

• Melting Point: 38-39°C
• Boiling Point: 341.0±34.0 °C(Predicted)
• PKA: 14.16±0.10(Predicted)
• PSA: 55.76000
• Density: 1.139±0.06 g/cm3(Predicted)
• LogP: 2.49280
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Ethyl Acetate, Methanol

Purity/Quality:

97% ^*data from raw suppliers

4-(tert-Butoxycarbonyloxy)benzylalcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(tert-Butoxycarbonyloxy)benzylalcohol

There total 5 articles about 4-(tert-Butoxycarbonyloxy)benzylalcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(4-hydroxyphenyl)methanol (623-05-2) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (4-(hydroxymethyl)phenyl)carbonate (156281-11-7)

Guidance literature:

With carbon tetrabromide; at 65 ℃; for 0.75h; chemoselective reaction; Neat (no solvent);

DOI:10.1021/jo8013325

Reference yield: 91.0%

(4-hydroxyphenyl)methanol (623-05-2) + 1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline (404586-94-3) → tert-butyl (4-(hydroxymethyl)phenyl)carbonate (156281-11-7)

Guidance literature:

In benzene; for 3h; Heating;

DOI:10.1021/ol017183u DOI:10.1016/j.tet.2006.09.063

Reference yield: 70.0%

(4-hydroxyphenyl)methanol (623-05-2) + di-tert-butyl dicarbonate (24424-99-5) → 1-(tert-butoxycarbonyloxy)-4-[(tert-butoxycarbonyloxy)methyl]benzene (1040380-05-9) + tert-butyl (4-(hydroxymethyl)phenyl)carbonate (156281-11-7)

Guidance literature:

With potassium carbonate; at 65 ℃; for 1h; Reagent/catalyst; Solvent; Temperature; Time; Reactivity;

DOI:10.1021/jo8013325

upstream raw materials:

(4-hydroxyphenyl)methanol

1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline

di-tert-butyl dicarbonate

para-tert-butoxycarbonyloxybenzaldehyde

Downstream raw materials:

tert-butyl (4-(chloromethyl)phenyl)carbonate

C₁₇H₁₇NO₈

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