Oxazole, 2-[2'-(1,3-dioxolan-2-yl)[1,1'-biphenyl]-2-yl]-4,5-dihydro-4,4-dimethyl-

Base Information

Chemical Name:Oxazole, 2-[2'-(1,3-dioxolan-2-yl)[1,1'-biphenyl]-2-yl]-4,5-dihydro-4,4-dimethyl-
CAS No.:156574-96-8
Molecular Formula:C₂₀H₂₁NO₃
Molecular Weight:323.392
Hs Code.:
Mol file:156574-96-8.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Oxazole, 2-[2'-(1,3-dioxolan-2-yl)[1,1'-biphenyl]-2-yl]-4,5-dihydro-4,4-dimethyl-

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of Oxazole, 2-[2'-(1,3-dioxolan-2-yl)[1,1'-biphenyl]-2-yl]-4,5-dihydro-4,4-dimethyl-

There total 1 articles about Oxazole, 2-[2'-(1,3-dioxolan-2-yl)[1,1'-biphenyl]-2-yl]-4,5-dihydro-4,4-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 34824-58-3
2-(2-bromophenyl)-1,3-dioxolan

: 156574-96-8
4,4-dimethyl-2-<2-(2-<1,3-dioxolan-2-yl>phenyl)phenyl>oxazoline

Guidance literature:: With magnesium; Yield given. Multistep reaction; 1.) THF, reflux, 20 min, 2.) THF, RT, 16 h;
DOI:10.1080/00397919408010202

Reference yield:

: 156574-96-8
4,4-dimethyl-2-<2-(2-<1,3-dioxolan-2-yl>phenyl)phenyl>oxazoline

: 5-phenyl)methyl>-1H-tetrazole

Guidance literature:: Multi-step reaction with 5 steps

1: 59 percent / aq. HCl / 2 h / Ambient temperature

2: 1.) NH₄Cl, Al₂O₃ / 1.) acetonitrile, ultrasonification, 1 h, 2.) acetonitrile, ultrasonification, overnight

3: 76 percent / tributyltin azide / 48 h / 90 °C

4: 60 percent / conc. HCl / 16 h / Heating

5: 30 percent / aq. NaOH / 16 h / 100 °C

With hydrogenchloride; aluminum oxide; sodium hydroxide; tributyltin azide; ammonium chloride;
DOI:10.1080/00397919408010202

Reference yield:

: 156574-96-8
4,4-dimethyl-2-<2-(2-<1,3-dioxolan-2-yl>phenyl)phenyl>oxazoline

: 156575-04-1
5-phenyl)methyl>-1H-tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1: 59 percent / aq. HCl / 2 h / Ambient temperature

2: 1.) NH₄Cl, Al₂O₃ / 1.) acetonitrile, ultrasonification, 1 h, 2.) acetonitrile, ultrasonification, overnight

3: 76 percent / tributyltin azide / 48 h / 90 °C

With hydrogenchloride; aluminum oxide; tributyltin azide; ammonium chloride;
DOI:10.1080/00397919408010202