2-Isopropenylquinoline

Base Information

• Chemical Name: 2-Isopropenylquinoline
• CAS No.: 15825-90-8
• Molecular Formula: C₁₂H₁₁N
• Molecular Weight: 169.226
• DSSTox Substance ID: DTXSID30490839
• Nikkaji Number: J801.375F
• Wikidata: Q82334868
• Mol file: 15825-90-8.mol

Synonyms:2-Isopropenylquinoline;2-prop-1-en-2-ylquinoline;15825-90-8;SCHEMBL611196;2-(Prop-1-en-2-yl)quinoline;DTXSID30490839

Chemical Property of 2-Isopropenylquinoline

Chemical Property:

• PSA: 12.89000
• LogP: 3.26790
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 169.089149355
• Heavy Atom Count: 13
• Complexity: 197

Purity/Quality:

2-(1-methylethenyl)-Quinoline 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=C)C1=NC2=CC=CC=C2C=C1

Technology Process of 2-Isopropenylquinoline

There total 5 articles about 2-Isopropenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-ethylquinoline (1613-34-9) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 2-(prop-1-en-2-yl)quinoline (15825-90-8)

Guidance literature:

With diethyl amine hydrochloride; triethylamine; In 1,4-dioxane; at 100 ℃; for 3h;

DOI:10.1039/c5ra21304e

Reference yield: 40.0%

1-α-quinolylisopropanol (33696-40-1) → 2-(prop-1-en-2-yl)quinoline (15825-90-8)

Guidance literature:

With pyridine; thionyl chloride; for 3h; Heating;

Reference yield: 40.0%

2-bromoprop-1-ene (557-93-7) + 2-(9-Bora-bicyclo[3.3.1]non-9-yl)-quinoline → 2-(prop-1-en-2-yl)quinoline (15825-90-8)

Guidance literature:

With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; In benzene; for 8h; Heating;

upstream raw materials:

1-α-quinolylisopropanol

2-bromoprop-1-ene

quinoline-2-carboxylic acid methyl ester

2-ethylquinoline

Downstream raw materials:

2-[1-Methyl-2-(4-m-tolyl-piperazin-1-yl)-ethyl]-quinoline

1-phenyl-4-<β-(2-quinolyl)ethyl-β-methyl>piperazine