2-Ethylquinoline

Base Information

• Chemical Name: 2-Ethylquinoline
• CAS No.: 1613-34-9
• Molecular Formula: C11H11 N
• Molecular Weight: 157.215
• Hs Code.: 2933499090
• Mol file: 1613-34-9.mol

Synonyms:2-Ethylquinoline

Chemical Property of 2-Ethylquinoline

Chemical Property:

• Vapor Pressure: 0.0448mmHg at 25°C
• Melting Point: 51.53°C (estimate)
• Refractive Index: 1.5979
• Boiling Point: 245.5°Cat760mmHg
• PKA: 5.86±0.40(Predicted)
• Flash Point: 98.7°C
• PSA: 12.89000
• Density: 1.05g/cm³
• LogP: 2.79720

Purity/Quality:

99%min ^*data from raw suppliers

2-ethylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Ethylquinoline

There total 68 articles about 2-Ethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-methylquinoline (91-63-4) + methyl iodide (74-88-4) → 2-ethylquinoline (1613-34-9)

Guidance literature:

2-methylquinoline; With sec.-butyllithium; In diethyl ether; cyclohexane; at 0 - 20 ℃; for 1.5h;

methyl iodide; In diethyl ether; cyclohexane; at 0 - 20 ℃; for 3h;

Reference yield: 90.0%

2-Aminobenzyl alcohol (5344-90-1) + iso-butanol (78-92-2,15892-23-6) → 2-ethylquinoline (1613-34-9)

Guidance literature:

With C₅₁H₄₁ClN₂O₃P₂Ru*C₂H₃N; potassium hydroxide; In 1,4-dioxane; at 100 ℃; for 8h;

DOI:10.1080/00958972.2017.1381692

Reference yield: 86.0%

ortho-azido-β-nitrostyrene + butanone (78-93-3) → 2-ethylquinoline (1613-34-9)

Guidance literature:

ortho-azido-β-nitrostyrene; butanone; With triethylamine; L-proline; In dichloromethane; at 20 ℃; Inert atmosphere;

With triphenylphosphine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2013.07.050

upstream raw materials:

quinoline

ethene

2-methylquinoline

quinolin-2-ylmethylbromide

Downstream raw materials:

2-vinylquinoline

1-quinolin-2-yl-ethanone

2-(propionylamino)benzoic acid

quinoline-2-carboxylic acid

Refernces

• 1、 Bradley,Jeffrey. "-". . p. 2770,2776. Retrieved 1954.
• 2、 Gao, Zhuyan,Huang, Zhipeng,Lu, Jianmin,Mu, Junju,Ren, Puning,Su, Kaiyi,Wang, Feng,Zhang, Chaofeng,Zhang, Shichao. "Oxygen-implanted MoS2 nanosheets promoting quinoline synthesis from nitroarenes and aliphatic alcohols via an integrated oxidation transfer hydrogenation-cyclization mechanism". . p. 1704 - 1713. Retrieved 2022/03/08.
• 3、 -. "SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR". . . Retrieved 2020/08/16.