5-hydrazino-1-phenyl-1H-tetrazole

Base Information

• Chemical Name: 5-hydrazino-1-phenyl-1H-tetrazole
• CAS No.: 5533-43-7
• Molecular Formula: C7H8 N6
• Molecular Weight: 176.181
• Hs Code.: 2933990090
• Mol file: 5533-43-7.mol

Synonyms:1H-Tetrazole,5-hydrazino-1-phenyl- (7CI,8CI); 5H-Tetrazol-5-one, 1,2-dihydro-1-phenyl-,hydrazone (9CI); NSC 282019

Chemical Property of 5-hydrazino-1-phenyl-1H-tetrazole

Chemical Property:

• Vapor Pressure: 3.94E-06mmHg at 25°C
• Boiling Point: 385°C at 760 mmHg
• Flash Point: 186.6°C
• PSA: 81.65000
• Density: 1.53g/cm³
• LogP: 0.72120

Purity/Quality:

98% ^*data from raw suppliers

5-hydrazino-1-phenyl-1H-tetrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-hydrazino-1-phenyl-1H-tetrazole

There total 6 articles about 5-hydrazino-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

5-methylsulfanyl-1-phenyl-1H-tetrazole (1455-92-1) → 5-hydrazinyl-1-phenyl-1H-tetrazole (5533-43-7)

Guidance literature:

With pyridine; hydrazine hydrate; for 24h; Reflux;

DOI:10.3184/174751915X14428472915706

Reference yield:

phenyl carbamate (64-10-8) → 5-hydrazinyl-1-phenyl-1H-tetrazole (5533-43-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 80 percent / Pb(OAc)2; aq. KOH / 0.08 h / 100 °C

2.1: 66 percent / NaN₃; NH₄Cl / dimethylformamide / 2.5 h / 80 °C

3.1: aq. NaNO₂; HCl / 1 h / 0 °C

3.2: 28 percent / Zn; aq. AcOH / 0.5 h / 10 °C

With hydrogenchloride; potassium hydroxide; sodium azide; lead acetate; ammonium chloride; sodium nitrite; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00149-X

Reference yield:

1-phenylcyanamide (622-34-4) → 5-hydrazinyl-1-phenyl-1H-tetrazole (5533-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 66 percent / NaN₃; NH₄Cl / dimethylformamide / 2.5 h / 80 °C

2.1: aq. NaNO₂; HCl / 1 h / 0 °C

2.2: 28 percent / Zn; aq. AcOH / 0.5 h / 10 °C

With hydrogenchloride; sodium azide; ammonium chloride; sodium nitrite; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00149-X

upstream raw materials:

5-bromo-1-phenyl-1H-tetrazole

phenyl carbamate

1-phenylcyanamide

phenyl-1H-tetrazole

Refernces

• 1、 Yamazaki, Kazuto,Hasegawa, Hirohiko,Umekawa, Kayo,Ueki, Yasuyuki,Ohashi, Naohito,Kanaoka, Masaharu. "Design, synthesis and biological activity of novel non-peptidyl endothelin converting enzyme inhibitors, 1-phenyl-tetrazole-formazan analogues". . p. 1275 - 1278. Retrieved 2007/10/03.