4,6-Quinazolinediamine

Base Information

Chemical Name:4,6-Quinazolinediamine
CAS No.:159382-23-7
Molecular Formula:C8H8N4
Molecular Weight:160.178
Hs Code.:
DSSTox Substance ID:DTXSID70401020
Nikkaji Number:J688.813E
Wikidata:Q82204086
Mol file:159382-23-7.mol

Synonyms:Quinazoline-4,6-diamine;4,6-Diaminoquinazoline;4,6-Quinazolinediamine;159382-23-7;quinazolin-4,6-diamine;SCHEMBL4692556;DTXSID70401020;RNWDENXDCQXZLH-UHFFFAOYSA-N;AKOS013913024;FT-0666390

Suppliers and Price of 4,6-Quinazolinediamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4,6-Diaminoquinazoline
10g
$ 1320.00

American Custom Chemicals Corporation
4,6-DIAMINOQUINAZOLINE 95.00%
5MG
$ 500.14

Abosyn
Quinazoline-4,6-diamine >95%
10g
$ 1200.00

Abosyn
Quinazoline-4,6-diamine >95%
1g
$ 150.00

Total 1 raw suppliers

Chemical Property of 4,6-Quinazolinediamine

Chemical Property:

PSA：78.55000
LogP:1.30550
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:160.074896272
Heavy Atom Count:12
Complexity:161

Purity/Quality:: 4,6-Diaminoquinazoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=C1N)C(=NC=N2)N
Uses 4,6-Diaminoquinazoline is used in the preparation of potential nociceptin receptor (NOP) antagonists. 4,6-Diaminoquinazoline is a predicted metabolite of 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline (A621350).

Technology Process of 4,6-Quinazolinediamine

There total 5 articles about 4,6-Quinazolinediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 49675-68-5
6-nitroquinazoline-4-(3H)-imine

: 159382-23-7
quinazoline-4,6-diamine

Guidance literature:: With tin(II) chloride dihdyrate; In methanol; for 3h; Reflux; Inert atmosphere;
DOI:10.1248/cpb.c14-00560

Reference yield: 78.1%

: 49675-68-5
4-amino-6-nitroquinazoline

: 159382-23-7
quinazoline-4,6-diamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In 2-methoxy-ethanol;
DOI:10.1016/0006-2952(95)00203-C

Reference yield:

: 17420-30-3
5-nitroanthranilonitrile

: 159382-23-7
quinazoline-4,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / 3 h / 170 °C

2: 78.1 percent / H₂ / 10 percent Pd/C / 2-methoxy-ethanol

With hydrogen; palladium on activated charcoal; In 2-methoxy-ethanol;
DOI:10.1016/0006-2952(95)00203-C