FMOC-D-PHE-OPFP

Base Information

• Chemical Name: FMOC-D-PHE-OPFP
• CAS No.: 159505-85-8
• Molecular Formula: C30H20F5NO4
• Molecular Weight: 553.47600
• Mol file: 159505-85-8.mol

Synonyms:Pentafluorophenyl N-Fmoc-D-phenylalaninate;Pentafluorophenyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalaninate;Perfluorophenyl [[(9H-fluoren-9-yl)methoxy]carbonyl]-D-phenylalaninate;D-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, pentafluorophenyl ester;

Chemical Property of FMOC-D-PHE-OPFP

Chemical Property:

• Appearance/Colour: Solid
• PSA: 64.63000
• LogP: 6.82840
• Storage Temp.: Store at 0°C

Purity/Quality:

>98% ^*data from raw suppliers

Fmoc-D-Phe-OPfp ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-D-PHE-OPFP

There total 10 articles about FMOC-D-PHE-OPFP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

pentafluorophenyl trifloroacetate (14533-84-7) + N-Fmoc L-Phe (35661-40-6) → N-α-Fmoc-L-phenylalanine pentafluorophenyl ester (86060-92-6,159505-85-8)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; for 0.75h; Ambient temperature;

DOI:10.1016/S0040-4039(00)97976-0

Reference yield: 93.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + N-Fmoc L-Phe (35661-40-6) → N-α-Fmoc-L-phenylalanine pentafluorophenyl ester (86060-92-6,159505-85-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; 0 deg C, 1 h; r.t., 1 h;

DOI:10.1055/s-1983-30327

Reference yield: 93.0%

N-Fmoc L-Phe (35661-40-6) + bis(pentafluorophenyl)sulfite (96157-57-2) → N-α-Fmoc-L-phenylalanine pentafluorophenyl ester (86060-92-6,159505-85-8)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1007/BF00952635

upstream raw materials:

2,3,4,5,6-pentafluorophenol

N-Fmoc L-Phe

2S-flouren-9-ylmethoxycarbonylamino-3-phenylpropionyl chloride

pentafluorophenyl trifloroacetate

Downstream raw materials:

Asp-Phe-NH₂

3-[(S)-2-{(S)-6-Amino-2-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-hexanoylamino}-3-(4-hydroxy-phenyl)-propionylamino]-propionic acid

H-Phe-Val-Trp-Ile-NH₂

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