Propanamide, N-[3-[3-butyl-4-[[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl] methyl]-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-4-(trifluoromethyl)phenyl ]-

Base Information

Chemical Name:Propanamide, N-[3-[3-butyl-4-[[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl] methyl]-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-4-(trifluoromethyl)phenyl ]-
CAS No.:159954-94-6
Molecular Formula:C33H38F3N5O4S
Molecular Weight:657.757
Hs Code.:
Mol file:159954-94-6.mol

Propanamide,
N-[3-[3-butyl-4-[[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]
methyl]-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-4-(trifluoromethyl)phenyl
]-

Synonyms:

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Chemical Property of Propanamide, N-[3-[3-butyl-4-[[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl] methyl]-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-4-(trifluoromethyl)phenyl ]-

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Technology Process of Propanamide, N-[3-[3-butyl-4-[[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl] methyl]-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-4-(trifluoromethyl)phenyl ]-

There total 6 articles about Propanamide, N-[3-[3-butyl-4-[[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl] methyl]-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-4-(trifluoromethyl)phenyl ]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 598-22-1
propanoyl bromide

: 159954-93-5
2-<5-amino-2-(trifluoromethyl)phenyl>-5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)biphenyl-4-yl>methyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

: 159954-94-6
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)biphenyl-4-yl>methyl>-2,4-dihydro-2-<5-(propionylamino)-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one

Guidance literature:: With pyridine; dmap; Ambient temperature;
DOI:10.1021/jm00052a006

Reference yield:

: 100367-78-0
(2-bromo-5-nitrophenyl)hydrazine

: 159954-94-6
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)biphenyl-4-yl>methyl>-2,4-dihydro-2-<5-(propionylamino)-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / toluene / 15 h / 90 °C

2: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 1.5 h

3: 37 percent / KF, CuI / dimethylformamide / 12 h / 120 °C

4: 100 percent / H₂ / PtO₂ / ethyl acetate; ethanol / 3040 Torr

5: 90 percent / DMAP, pyridine / Ambient temperature

With pyridine; dmap; potassium fluoride; copper(l) iodide; hydrogen; sodium hydride; triethylamine; platinum(IV) oxide; In ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00052a006

Reference yield:

: 146949-06-6
ethyl N-carbethoxy-valerimidate

: 159954-94-6
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)biphenyl-4-yl>methyl>-2,4-dihydro-2-<5-(propionylamino)-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / toluene / 15 h / 90 °C

2: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 1.5 h

3: 37 percent / KF, CuI / dimethylformamide / 12 h / 120 °C

4: 100 percent / H₂ / PtO₂ / ethyl acetate; ethanol / 3040 Torr

5: 90 percent / DMAP, pyridine / Ambient temperature

With pyridine; dmap; potassium fluoride; copper(l) iodide; hydrogen; sodium hydride; triethylamine; platinum(IV) oxide; In ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00052a006