Propanamide, N-[3-[4-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-3-butyl-4,5-dihydro -5-oxo-1H-1,2,4-triazol-1-yl]-4-(trifluoromethyl)phenyl]-

Base Information

Chemical Name:Propanamide, N-[3-[4-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-3-butyl-4,5-dihydro -5-oxo-1H-1,2,4-triazol-1-yl]-4-(trifluoromethyl)phenyl]-
CAS No.:159954-95-7
Molecular Formula:C29H30F3N5O4S
Molecular Weight:601.65
Hs Code.:
Mol file:159954-95-7.mol

Propanamide,
N-[3-[4-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-3-butyl-4,5-dihydro
-5-oxo-1H-1,2,4-triazol-1-yl]-4-(trifluoromethyl)phenyl]-

Synonyms:

Suppliers and Price of Propanamide, N-[3-[4-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-3-butyl-4,5-dihydro -5-oxo-1H-1,2,4-triazol-1-yl]-4-(trifluoromethyl)phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Propanamide, N-[3-[4-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-3-butyl-4,5-dihydro -5-oxo-1H-1,2,4-triazol-1-yl]-4-(trifluoromethyl)phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Propanamide, N-[3-[4-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-3-butyl-4,5-dihydro -5-oxo-1H-1,2,4-triazol-1-yl]-4-(trifluoromethyl)phenyl]-

There total 7 articles about Propanamide, N-[3-[4-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-3-butyl-4,5-dihydro -5-oxo-1H-1,2,4-triazol-1-yl]-4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 159954-94-6
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)biphenyl-4-yl>methyl>-2,4-dihydro-2-<5-(propionylamino)-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one

: 159954-95-7
5-n-butyl-2,4-dihydro-2-<5-(propionylamino)-2-(trifluoromethyl)phenyl>-4-<(2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

Guidance literature:: With methoxybenzene; trifluoroacetic acid; Ambient temperature;
DOI:10.1021/jm00052a006

Reference yield:

: 100367-78-0
(2-bromo-5-nitrophenyl)hydrazine

: 159954-95-7
5-n-butyl-2,4-dihydro-2-<5-(propionylamino)-2-(trifluoromethyl)phenyl>-4-<(2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / toluene / 15 h / 90 °C

2: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 1.5 h

3: 37 percent / KF, CuI / dimethylformamide / 12 h / 120 °C

4: 100 percent / H₂ / PtO₂ / ethyl acetate; ethanol / 3040 Torr

5: 90 percent / DMAP, pyridine / Ambient temperature

6: 91 percent / anisole, TFA / Ambient temperature

With pyridine; dmap; potassium fluoride; copper(l) iodide; hydrogen; sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; platinum(IV) oxide; In ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00052a006

Reference yield:

: 146949-06-6
ethyl N-carbethoxy-valerimidate

: 159954-95-7
5-n-butyl-2,4-dihydro-2-<5-(propionylamino)-2-(trifluoromethyl)phenyl>-4-<(2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / toluene / 15 h / 90 °C

2: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 1.5 h

3: 37 percent / KF, CuI / dimethylformamide / 12 h / 120 °C

4: 100 percent / H₂ / PtO₂ / ethyl acetate; ethanol / 3040 Torr

5: 90 percent / DMAP, pyridine / Ambient temperature

6: 91 percent / anisole, TFA / Ambient temperature

With pyridine; dmap; potassium fluoride; copper(l) iodide; hydrogen; sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; platinum(IV) oxide; In ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00052a006