(14alpha)-7,8-Didehydro-4-hydroxy-3-methoxy-17-methylmorphinan-6-one

Base Information

• Chemical Name: (14alpha)-7,8-Didehydro-4-hydroxy-3-methoxy-17-methylmorphinan-6-one
• CAS No.: 596-59-8
• Molecular Formula: C18H21 N O3
• Molecular Weight: 299.37
• European Community (EC) Number: 209-888-6
• DSSTox Substance ID: DTXSID101158215
• Mol file: 596-59-8.mol

Synonyms:EINECS 209-888-6;596-59-8;(14alpha)-7,8-Didehydro-4-hydroxy-3-methoxy-17-methylmorphinan-6-one;beta-Thebainone A;DTXSID101158215

Chemical Property of (14alpha)-7,8-Didehydro-4-hydroxy-3-methoxy-17-methylmorphinan-6-one

Chemical Property:

• PSA: 49.77000
• LogP: 1.98190
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 299.15214353
• Heavy Atom Count: 22
• Complexity: 505

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23CC(=O)C=CC2C1CC4=C3C(=C(C=C4)OC)O
• Isomeric SMILES: CN1CC[C@]23CC(=O)C=C[C@@H]2[C@H]1CC4=C3C(=C(C=C4)OC)O

Technology Process of (14alpha)-7,8-Didehydro-4-hydroxy-3-methoxy-17-methylmorphinan-6-one

There total 33 articles about (14alpha)-7,8-Didehydro-4-hydroxy-3-methoxy-17-methylmorphinan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

3,6-dimethoxy-17-methyl-morphina-5,8-dien-4-ol (6878-93-9) → 4-hydroxy-3-methoxy-17-methyl-14α-morphin-7-en-6-one (596-59-8)

Guidance literature:

With hydrogenchloride; at 95 ℃; for 0.583333h;

DOI:10.1080/00397919808005110

Reference yield: 8.0%

3,6-dimethoxy-17-methyl-morphina-5,8-dien-4-ol (6878-93-9) → 4-hydroxy-3-methoxy-17-methyl-14α-morphin-7-en-6-one (596-59-8) + 7,8-didehydro-4-hydroxy-3-methoxy-17-methyl-morphinan-6-one (467-98-1)

Guidance literature:

With hydrogenchloride; at 95 ℃; for 0.583333h;

DOI:10.1080/00397919808005110

Reference yield:

→ 4-hydroxy-3-methoxy-17-methyl-14α-morphin-7-en-6-one (596-59-8)

Guidance literature:

With hydrogenchloride; water;

DOI:10.1016/0040-4020(65)80056-4

upstream raw materials:

3,6-dimethoxy-17-methyl-morphina-5,8-dien-4-ol

thebaine

β-thebainone-A

ent-4-hydroxy-3-methoxy-17-methyl-morphin-7-en-6-one

Downstream raw materials:

(±)-thebainone A

(-)-Dihydrothebainon