Benzeneacetaldehyde, 3-(phenylmethoxy)-

Base Information

• Chemical Name: Benzeneacetaldehyde, 3-(phenylmethoxy)-
• CAS No.: 160721-23-3
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Mol file: 160721-23-3.mol

Synonyms:3-Benzyloxy-phenylacetaldehyd;(3-benzyloxy-phenyl)-acetaldehyde;(3-benzyloxyphenyl)acetaldehyde;(m-benzyloxy)phenylacetaldehyde;

Chemical Property of Benzeneacetaldehyde, 3-(phenylmethoxy)-

Chemical Property:

• PSA: 26.30000
• LogP: 3.00700

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetaldehyde, 3-(phenylmethoxy)-

There total 11 articles about Benzeneacetaldehyde, 3-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-[(3-(benzyloxy)phenyl)]ethan-1-ol (177259-98-2) → <3-(benzyloxy)phenyl>ethanal (160721-23-3)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 25 ℃; for 4h;

DOI:10.1021/acs.jmedchem.8b01466

Reference yield:

3-hydroxy-benzeneacetic acid, methyl ester (42058-59-3) → <3-(benzyloxy)phenyl>ethanal (160721-23-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: pyridinium chlorochromate / dichloromethane

With lithium aluminium tetrahydride; potassium carbonate; pyridinium chlorochromate; sodium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2020.112450

Reference yield:

ethyl 3-(benzyloxyphenyl)acetate (130604-43-2) → <3-(benzyloxy)phenyl>ethanal (160721-23-3)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;

DOI:10.1016/S0040-4039(00)74819-2

upstream raw materials:

ethyl 3-(benzyloxyphenyl)acetate

2-(3-benzyloxyphenyl)acetonitrile

m-hydroxyphenylacetic acid

ethyl 3-hydroxyphenylacetate

Downstream raw materials:

(Z)-4-(3-Benzyloxy-phenyl)-but-2-enoic acid ethyl ester

ethyl (E)-4-<3-(benzyloxy)phenyl>-2-butenoate

3-(3-hydroxyphenyl) butanal

5-(3-(benzyloxy)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione