4-(2,4-Dichlorophenyl)-1,3-thiazol-2-amine

Base Information

• Chemical Name: 4-(2,4-Dichlorophenyl)-1,3-thiazol-2-amine
• CAS No.: 93209-97-3
• Molecular Formula: C9H6 Cl2 N2 S
• Molecular Weight: 245.132
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID40351588
• Nikkaji Number: J2.765.238G
• Wikidata: Q82128116
• Mol file: 93209-97-3.mol

Synonyms:93209-97-3;4-(2,4-dichlorophenyl)-1,3-thiazol-2-amine;4-(2,4-dichlorophenyl)thiazol-2-amine;2-thiazolamine, 4-(2,4-dichlorophenyl)-;MFCD01114990;4-(2,4-Dichloro-phenyl)-thiazol-2-ylamine;2-Thiazolamine,4-(2,4-dichlorophenyl)-;thiazol-2-amine, 16;Cambridge id 5690421;Oprea1_328306;SCHEMBL129994;BDBM31184;DTXSID40351588;APJACVDBTHESJL-UHFFFAOYSA-N;HMS1726G04;BBL014153;STK299379;AKOS000116027;5K-651S;AM85273;2-Amino-4-(2,4-dichlorophenyl)thiazole;4-(2,4-dichlorophenyl)thiazol-2-ylamine;BB 0218665;FT-0678497;EN300-02789;4-(2,4-dichlorophenyl)-1,3-thiazol-2-ylamine;AB00093650-01;A844476;AK-968/37166377;SR-01000412623;J-513260;SR-01000412623-1;F0486-2735;4-(2,4-Dichlorophenyl)-1,3-thiazol-2-amine, AldrichCPR

Chemical Property of 4-(2,4-Dichlorophenyl)-1,3-thiazol-2-amine

Chemical Property:

• Vapor Pressure: 1.76E-06mmHg at 25°C
• Melting Point: 156-158°C
• Boiling Point: 396°Cat760mmHg
• Flash Point: 193.3°C
• PSA: 67.15000
• Density: 1.498g/cm³
• LogP: 4.28030
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 243.9628748
• Heavy Atom Count: 14
• Complexity: 205

Purity/Quality:

98%min ^*data from raw suppliers

4-(2,4-Dichlorophenyl)-1,3-thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)C2=CSC(=N2)N

Technology Process of 4-(2,4-Dichlorophenyl)-1,3-thiazol-2-amine

There total 7 articles about 4-(2,4-Dichlorophenyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.1%

→ 4-(2,4-dichlorophenyl)-1,3-thiazol-2-amine (93209-97-3)

Guidance literature:

Reference yield: 97.0%

thiourea (17356-08-0) + 2,2',4'-trichloroacetophenone (4252-78-2) → 4-(2,4-dichlorophenyl)-1,3-thiazol-2-amine (93209-97-3)

Guidance literature:

In ethylene glycol; at 20 ℃; for 0.5h;

DOI:10.1080/00397910802691874

Reference yield: 89.0%

2,4-dichlorophenacyl bromide (2631-72-3) + thiourea (17356-08-0) → 4-(2,4-dichlorophenyl)-1,3-thiazol-2-amine (93209-97-3)

Guidance literature:

In ethanol; at 100 ℃; for 0.25h; Sealed tube; Microwave irradiation; Inert atmosphere;

DOI:10.1016/j.tet.2014.06.102

upstream raw materials:

thiourea

2,2',4'-trichloroacetophenone

1-(2,4-dichlorophenyl)ethan-1-one

2,4-dichlorophenacyl bromide

Downstream raw materials:

N-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide

Refernces

• 1、 Ujwaldev, Sankuviruthiyil M.,Harry, Nissy Ann,Neetha, Mohan,Anilkumar, Gopinathan. "Novel synthesis of 2-Aminothiazoles via Fe(III)-Iodine-catalyzed Hantzsch-type condensation". supporting information. p. 646 - 653. Retrieved 2020/10/20.
• 2、 Alsayed, Shahinda S. R.,Beh, Chau Chun,Bishai, William R.,Foster, Neil,Gunosewoyo, Hendra,Lun, Shichun,Luna, Giuseppe,Payne, Alan D.. "Design, synthesis, and biological evaluation of novel arylcarboxamide derivatives as anti-tubercular agents". . p. 7523 - 7540. Retrieved 2020/03/13.