Welcome to LookChem.com Sign In|Join Free

CAS

  • or

2631-72-3

Post Buying Request

2631-72-3 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

2631-72-3 Usage

Chemical Properties

White to brown low melting solid

Uses

2-Bromo-2',4'-dichloroacetophenone is a metabolite of the insecticide Bromfenvinphos. It is also a useful intermediate in the preparation of substituted acetophenone derivatives.

Check Digit Verification of cas no

The CAS Registry Mumber 2631-72-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,3 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2631-72:
(6*2)+(5*6)+(4*3)+(3*1)+(2*7)+(1*2)=73
73 % 10 = 3
So 2631-72-3 is a valid CAS Registry Number.

2631-72-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H59615)  2-Bromo-2',4'-dichloroacetophenone, 95%   

  • 2631-72-3

  • 1g

  • 678.0CNY

  • Detail
  • Alfa Aesar

  • (H59615)  2-Bromo-2',4'-dichloroacetophenone, 95%   

  • 2631-72-3

  • 5g

  • 2184.0CNY

  • Detail

2631-72-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-bromo-2’,4’-dichloroacetophenone

1.2 Other means of identification

Product number -
Other names 2,4-Dichlorophenacyl Bromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2631-72-3 SDS

2631-72-3Synthetic route

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

Conditions
ConditionsYield
With bromine In 1,4-dioxane; diethyl ether for 0.5h; Ambient temperature;100%
With copper(ll) bromide In chloroform; ethyl acetate at 40℃; for 2h;100%
With dihydrogen peroxide; bromine; sodium carbonate In dichloromethane at 20 - 40℃; Green chemistry;91.4%
1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

A

2,2-dibromo-1-(2,4-dichlorophenyl)ethanone
24123-68-0

2,2-dibromo-1-(2,4-dichlorophenyl)ethanone

B

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

Conditions
ConditionsYield
With trimethylsilyl bromide; potassium nitrate In dichloromethane at 20℃; for 48h;A n/a
B 72%
2,2-dibromo-1-(2,4-dichlorophenyl)ethanone
24123-68-0

2,2-dibromo-1-(2,4-dichlorophenyl)ethanone

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

B

O,O-dimethyl-O-<1-(2,4-dichlorophenyl)-2-bromo>vinyl phosphate (isomer Z)
68107-01-7

O,O-dimethyl-O-<1-(2,4-dichlorophenyl)-2-bromo>vinyl phosphate (isomer Z)

Conditions
ConditionsYield
In methanol for 0.25h; Heating; Title compound not separated from byproducts;A 45%
B 10%
1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

A

α-bromo-2,4-dibromoacetophenone
60208-07-3

α-bromo-2,4-dibromoacetophenone

B

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

Conditions
ConditionsYield
With bromine In acetic acid at 35 - 40℃; for 2h;
diethyl ether
60-29-7

diethyl ether

water
7732-18-5

water

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

Conditions
ConditionsYield
With bromine
bromoacetic anhydride
13094-51-4

bromoacetic anhydride

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

Conditions
ConditionsYield
Stage #1: bromoacetic anhydride With aluminum (III) chloride In dichloromethane at 25℃; for 0.5h;
Stage #2: 1,3-Dichlorobenzene In dichloromethane for 16h; Reflux;
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

Conditions
ConditionsYield
Stage #1: 2-Bromoacetyl bromide With aluminum (III) chloride In dichloromethane at 25℃; for 0.5h;
Stage #2: 1,3-Dichlorobenzene In dichloromethane for 16h; Reflux;
1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / 1,2-dichloro-benzene / 0.33 h
1.2: Cooling with ice
2.1: aluminum (III) chloride; bromine / diethyl ether / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: calcium chloride; hydrogenchloride; aluminum (III) chloride / water / 0.83 h
2: aluminum (III) chloride; bromine / diethyl ether / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: 4 h / 60 °C / Ionic liquid; Green chemistry
2: dihydrogen peroxide; sodium carbonate; bromine / dichloromethane / 20 - 40 °C / Green chemistry
View Scheme
2-bromoacetyl chloride
22118-09-8

2-bromoacetyl chloride

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

Conditions
ConditionsYield
With aluminum (III) chloride for 0.666667h; Friedel-Crafts Acylation; Cooling with ice; Inert atmosphere;
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

2-mercapto-5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazole
63698-52-2

2-mercapto-5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazole

2-(5-Benzo[1,3]dioxol-5-yl-[1,3,4]oxadiazol-2-ylsulfanyl)-1-(2,4-dichloro-phenyl)-ethanone
146942-90-7

2-(5-Benzo[1,3]dioxol-5-yl-[1,3,4]oxadiazol-2-ylsulfanyl)-1-(2,4-dichloro-phenyl)-ethanone

Conditions
ConditionsYield
With sodium hydroxide In ethanol98%
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

(S)-2-bromo-1-(2,4-dichlorophenyl)ethan-1-ol
187164-20-1

(S)-2-bromo-1-(2,4-dichlorophenyl)ethan-1-ol

Conditions
ConditionsYield
With B-chlorodiisopinocampheylborane In tetrahydrofuran at -25℃; for 16h;98%
Stage #1: 2,4-dichlorophenacyl bromide With borane Ν,Ν-diethylaniline complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole In tetrahydrofuran; toluene at 20 - 30℃; for 1h;
Stage #2: With methanol In tetrahydrofuran; toluene Cooling;
72%
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-(2, 4-dichlorophenyl)quinoxaline
930781-40-1

2-(2, 4-dichlorophenyl)quinoxaline

Conditions
ConditionsYield
With polymeric resin-bound hexafluorophosphate ion In methanol; water at 20℃; for 6.5h;98%
With potassium fluoride on basic alumina at 20℃; for 2h;93%
With γ-maghemite-silica nanocomposite In neat (no solvent) for 6h; Green chemistry;88%
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

malononitrile
109-77-3

malononitrile

2-(2-(3,4-dichlorophenyl)-2-oxoethyl)malononitrile
141776-18-3

2-(2-(3,4-dichlorophenyl)-2-oxoethyl)malononitrile

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran97.5%
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

4-fluoro-3-hydroxy benzonitrile

4-fluoro-3-hydroxy benzonitrile

3-(2-(2,4-dichlorophenyl)-2-oxoethoxy)-4-fluorobenzonitrile

3-(2-(2,4-dichlorophenyl)-2-oxoethoxy)-4-fluorobenzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 1.8h;97%
4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

Purpald(R)
1750-12-5

Purpald(R)

(E)-(2,4-dichlorophenyl)(3-(2-(4-methylbenzylidene)hydrazinyl)-6-(p-tolyl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl)methanone

(E)-(2,4-dichlorophenyl)(3-(2-(4-methylbenzylidene)hydrazinyl)-6-(p-tolyl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl)methanone

Conditions
ConditionsYield
With triethylamine In ethanol for 4h; Reflux;97%
ethylene glycol
107-21-1

ethylene glycol

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane

2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 30h; Reflux;96%
With toluene-4-sulfonic acid In butan-1-ol; benzene for 6h; Reflux;92.54%
With toluene-4-sulfonic acid In butan-1-ol; benzene at 87 - 88.5℃; for 5h; Reagent/catalyst; Solvent; Temperature;83.22%
thiosemicarbazide
79-19-6

thiosemicarbazide

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

3,4-dihydronaphthalene-1(2H)-one
529-34-0

3,4-dihydronaphthalene-1(2H)-one

4-(2,4-dichlorophenyl)-2-(2-(3,4-dihydronaphthalen-1(2H)-ylidene)hydrazinyl)thiazole

4-(2,4-dichlorophenyl)-2-(2-(3,4-dihydronaphthalen-1(2H)-ylidene)hydrazinyl)thiazole

Conditions
ConditionsYield
In neat (no solvent) at 20℃; for 0.0833333h; Solvent; Temperature; regioselective reaction;96%
2-aminopyridine
504-29-0

2-aminopyridine

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

C13H7BrCl2N2

C13H7BrCl2N2

Conditions
ConditionsYield
With tert.-butylhydroperoxide In ethyl acetate at 90℃; for 3h;96%
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole-2-thiol
23269-92-3

5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole-2-thiol

1-(2,4-Dichloro-phenyl)-2-[5-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-ethanone
146942-88-3

1-(2,4-Dichloro-phenyl)-2-[5-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-ethanone

Conditions
ConditionsYield
With sodium hydroxide In ethanol95%
In acetone at 40℃; for 1h;80%
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

diethyl 1H-pyrazole-3,5-dicarboxylate
37687-24-4

diethyl 1H-pyrazole-3,5-dicarboxylate

diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate
1101323-82-3

diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 12h;94%
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

2-bromo-1-(2,4-dichlorophenyl)ethanol
53066-15-2

2-bromo-1-(2,4-dichlorophenyl)ethanol

Conditions
ConditionsYield
Stage #1: 2,4-dichlorophenacyl bromide With sodium tetrahydroborate In methanol at 0 - 20℃; for 1.5h; Inert atmosphere;
Stage #2: With water In methanol
94%
With sodium tetrahydroborate In isopropyl alcohol at 3 - 20℃; for 2h;57%
5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol
418776-10-0

5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

1-(2,4-dichlorophenyl)-2-[(5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazol-3-yl)thio]ethanone

1-(2,4-dichlorophenyl)-2-[(5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazol-3-yl)thio]ethanone

Conditions
ConditionsYield
Stage #1: 5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol With sodium ethanolate In ethanol for 0.0666667h; Sonication; Green chemistry;
Stage #2: 2,4-dichlorophenacyl bromide In ethanol for 0.1h; Sonication; Green chemistry;
94%
5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-benzyl-4H-1,2,4-triazole-3-thiol

5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-benzyl-4H-1,2,4-triazole-3-thiol

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

2-[(4-benzyl-5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4H-1,2,4-triazol-3-yl)thio]-1-(2,4-dichlorophenyl)ethanone

2-[(4-benzyl-5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4H-1,2,4-triazol-3-yl)thio]-1-(2,4-dichlorophenyl)ethanone

Conditions
ConditionsYield
Stage #1: 5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-benzyl-4H-1,2,4-triazole-3-thiol With sodium ethanolate In ethanol for 0.0666667h; Sonication; Green chemistry;
Stage #2: 2,4-dichlorophenacyl bromide In ethanol for 0.1h; Sonication; Green chemistry;
94%
benzoimidazole
51-17-2

benzoimidazole

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

2-(1H-benzo[d]imidazol-1-yl)-1-(2,4-dichlorophenyl)ethan-1-one

2-(1H-benzo[d]imidazol-1-yl)-1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
With triethylamine In acetone at 55℃; for 0.333333h; Sonication; Green chemistry;94%
(4-aminosulfonylphenyl)thiourea
1718-39-4

(4-aminosulfonylphenyl)thiourea

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

4-(4-(2,4-dichlorophenyl)thiazol-2-ylamino)benzenesulfonamide

4-(4-(2,4-dichlorophenyl)thiazol-2-ylamino)benzenesulfonamide

Conditions
ConditionsYield
In ethanol; N,N-dimethyl-formamide at 80℃; for 5h;93%
thiosemicarbazide
79-19-6

thiosemicarbazide

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

3-Nitroacetophenone
121-89-1

3-Nitroacetophenone

N-[4-(2,4-dichlorophenyl)thiazol-2-yl]-N'-[1-(3-nitrophenyl)ethylidine]hydrazine

N-[4-(2,4-dichlorophenyl)thiazol-2-yl]-N'-[1-(3-nitrophenyl)ethylidine]hydrazine

Conditions
ConditionsYield
Stage #1: thiosemicarbazide; 3-Nitroacetophenone With acetic acid at 70 - 75℃; for 1.3h; Green chemistry;
Stage #2: 2,4-dichlorophenacyl bromide at 70 - 75℃; for 0.416667h; Green chemistry;
93%
1-indanone thiosemicarbazone
74227-66-0

1-indanone thiosemicarbazone

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

N-indan-1-ylidene-N'-[4-(2,4-dichloro-phenyl)-thiazol-2-yl]-hydrazine

N-indan-1-ylidene-N'-[4-(2,4-dichloro-phenyl)-thiazol-2-yl]-hydrazine

Conditions
ConditionsYield
With triethylamine In ethanol at 80℃;93%
1H-imidazole
288-32-4

1H-imidazole

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanone
46503-52-0

1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanone

Conditions
ConditionsYield
With triethylamine In dichloromethane at 10℃; Reagent/catalyst;92%
In tetrahydrofuran at 20℃; for 1.5h; Inert atmosphere;87%
With potassium carbonate at 20℃;78%
4-(4-methoxyphenylsulfanyl)benzaldehyde thiosemicarbazone

4-(4-methoxyphenylsulfanyl)benzaldehyde thiosemicarbazone

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

4-(4-methoxyphenylsulfanyl)benzaldehyde [4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazone

4-(4-methoxyphenylsulfanyl)benzaldehyde [4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazone

Conditions
ConditionsYield
In ethanol at 100℃; under 7500.75 Torr; for 0.0833333h; Hantzsch Thiazole Synthesis; Microwave irradiation;92%
(Z)-3-chloro-3-(4-chlorophenyl)acrylaldehyde
14063-77-5, 88438-06-6

(Z)-3-chloro-3-(4-chlorophenyl)acrylaldehyde

thiosemicarbazide
79-19-6

thiosemicarbazide

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

2-{(2E)-2-[(2Z)-3-chloro-3-(4-chlorophenyl)prop-2-en-1-ylidene]hydrazinyl}-4-(2,4-dichlorophenyl)-1,3-thiazole

2-{(2E)-2-[(2Z)-3-chloro-3-(4-chlorophenyl)prop-2-en-1-ylidene]hydrazinyl}-4-(2,4-dichlorophenyl)-1,3-thiazole

Conditions
ConditionsYield
Stage #1: (Z)-3-chloro-3-(4-chlorophenyl)acrylaldehyde; thiosemicarbazide With acetic acid at 70 - 75℃; Green chemistry;
Stage #2: 2,4-dichlorophenacyl bromide Heating; Green chemistry;
92%
propylene glycol
57-55-6

propylene glycol

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

2-(2,4-dichlorophenyl)-2-bromomethyl-4-methyl-1,3-dioxolane

2-(2,4-dichlorophenyl)-2-bromomethyl-4-methyl-1,3-dioxolane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 4h; Reflux; Green chemistry;91.9%
1,2-pentanediol
5343-92-0

1,2-pentanediol

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

2-(bromomethyl)-2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolane

2-(bromomethyl)-2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 4h; Reflux;91.65%
C22H25FN6O2S

C22H25FN6O2S

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

ethyl 4-(4-{[(5-{[2-(2,4-dichlorophenyl)-2-oxoethyl]thio}-4-phenyl-4H-1,2,4-triazol-3-yl)methyl]amino}-2-fluorophenyl)piperazin-1-carboxylate

ethyl 4-(4-{[(5-{[2-(2,4-dichlorophenyl)-2-oxoethyl]thio}-4-phenyl-4H-1,2,4-triazol-3-yl)methyl]amino}-2-fluorophenyl)piperazin-1-carboxylate

Conditions
ConditionsYield
Stage #1: C22H25FN6O2S With sodium ethanolate In ethanol for 0.0666667h; Sonication; Green chemistry;
Stage #2: 2,4-dichlorophenacyl bromide In ethanol for 0.1h; Sonication; Green chemistry;
91%
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

5-(4-ethoxy-3,5-dimethoxy-phenyl)-3H-[1,3,4]oxadiazole-2-thione
63698-51-1

5-(4-ethoxy-3,5-dimethoxy-phenyl)-3H-[1,3,4]oxadiazole-2-thione

1-(2,4-Dichloro-phenyl)-2-[5-(4-ethoxy-3,5-dimethoxy-phenyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-ethanone
146942-94-1

1-(2,4-Dichloro-phenyl)-2-[5-(4-ethoxy-3,5-dimethoxy-phenyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-ethanone

Conditions
ConditionsYield
With sodium hydroxide In ethanol90%
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

ethyl 3-amino-3-(4-phenylpiperazino)propenoate

ethyl 3-amino-3-(4-phenylpiperazino)propenoate

5-(2,4-Dichloro-phenyl)-2-(4-phenyl-piperazin-1-yl)-1H-pyrrole-3-carboxylic acid ethyl ester

5-(2,4-Dichloro-phenyl)-2-(4-phenyl-piperazin-1-yl)-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol 15-20 min, reflux, 1-2 h, r.t.;90%
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

O,O-dimethyl-O-<1-(2,4-dichlorophenyl)-2-bromo>vinyl phosphate (isomer Z)
68107-01-7

O,O-dimethyl-O-<1-(2,4-dichlorophenyl)-2-bromo>vinyl phosphate (isomer Z)

B

2,4-dichlorophenacyl-O,O-dimethylphosphonate

2,4-dichlorophenacyl-O,O-dimethylphosphonate

C

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
In methanol for 0.25h; Title compound not separated from byproducts;A 90%
B 3.3%
C 3.3%
In methanol for 0.25h; Mechanism; Heating; other phenacyl and phenacylidene halides;
4-amino-3-(D-glucoheptonic-hexitol-1-yl)-1H-1,2,4-triazole-5-thione
219474-93-8

4-amino-3-(D-glucoheptonic-hexitol-1-yl)-1H-1,2,4-triazole-5-thione

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

6-(2,4-dichlorophenyl)-3-(D-glucoheptonic-hexitol-1-yl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine
1027801-77-9

6-(2,4-dichlorophenyl)-3-(D-glucoheptonic-hexitol-1-yl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine

Conditions
ConditionsYield
In ethanol for 4h; Heating;90%
5-acetyl-4-methylthiazole-2-amine
30748-47-1

5-acetyl-4-methylthiazole-2-amine

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

1-(6-(2,4-dichlorophenyl)-3-methylimidazo[2,1-b]thiazol-2-yl)ethanone

1-(6-(2,4-dichlorophenyl)-3-methylimidazo[2,1-b]thiazol-2-yl)ethanone

Conditions
ConditionsYield
With polyethylene glycol (PEG-400) In water for 0.133333h; Microwave irradiation; Green chemistry;90%

2631-72-3Relevant articles and documents

Discovery and high-throughput screening of heteroleptic iridium complexes for photoinduced hydrogen production

Goldsmith, Jonas I.,Hudson, William R.,Lowry, Michael S.,Anderson, Timothy H.,Bernhard, Stefan

, p. 7502 - 7510 (2005)

The catalytic process of photoinduced hydrogen generation via the reduction of water has been investigated. The use of parallel synthetic techniques has facilitated the synthesis of a 32 member library of heteroleptic iridium complexes that was screened, using high-throughput photophysical techniques, to identify six potential photosensitizers for use in catalytic photoinduced hydrogen production. A Pd/Ni thin film hydrogen selective sensor allowed for rapid quantification of hydrogen produced via illumination of aqueous systems of the photosensitizer, tris(2,2′-dipyridyl)dichlorocobalt ([Co(bpy) 3]Cl2), and triethanolamine (a sacrificial reductant) with ultra-bright light emitting diodes (LEDs). The use of an 8-well parallel photoreactor expedited the investigation of the hydrogen evolution process and facilitated mechanistic studies. All six compounds investigated produced considerably more hydrogen than commonly utilized photosensitizers and had relative quantum efficiencies of hydrogen production up to 37 times greater than that of Ru(bpy)32+.

BuChE-IDO1 inhibitor as well as preparation method and application thereof

-

Paragraph 0031-0036, (2021/04/26)

The invention relates to the field of medicines, and particularly discloses a BuChE-IDO1 inhibitor as well as a preparation method and application thereof. The 7-chlorine-3-substituted benzothiophene part of sertaconazole is chemically modified, the influence of the 7-chlorine-3-substituted benzothiophene part of sertaconazole on the in-vitro inhibitory activity of AChE, BuChE and IDO1 is explored, the target compound is further optimized, and the technical problems that an existing BuChE-IDO1 inhibitor is poor in pertinence and safety are solved. What is explored is that an appropriate substituent group introduced to a 2-benzothiazole ring can form additional interaction with surrounding amino acids and heme iron, so that the binding affinity of the analogue with BuChE and IDO1 is increased, and a new idea is broadened for more efficient and targeted treatment of advanced AD diseases.

Imidazole compound and preparation method and application thereof, organic solderable protective agent containing imidazole compound and surface treatment method

-

Paragraph 0152-0155; 0168-0171, (2020/05/05)

The invention relates to the technical field of precious metal surface treatment, and in particular, relates to the technical field of copper or copper alloy surface protection materials. The invention discloses a dichlorophenyl imidazole compound, an application of the dichlorophenyl imidazole compound serving as a film forming matter of an organic solderable protective agent, and an organic solderable protective agent. The invention also discloses an application of the compound in copper or copper alloy surface anti-oxidation treatment, and a surface treatment method of the copper or copperalloy, wherein the method comprises the following steps: infiltrating the surface of the copper or copper alloy with the organic weldable protective agent containing the compound, and drying to generate a coating layer on the surface.

Novel thiazole–pyrazolone hybrids as potent ACE inhibitors and their cardioprotective effect on isoproterenol-induced myocardial infarction

You, Hongwen,Su, Xinyou,Su, Guoying

, (2020/08/27)

A facile synthesis of a group of novel thiazole–pyrazolone hybrids and their investigation for angiotensin-converting enzyme (ACE) inhibition are reported in this study. These compounds were synthesized using a well-known approach, based on the condensation of ethyl acetoacetate with thiazolylhydrazines, and characterized by various spectroscopic and analytical techniques. The entire set of compounds displayed a moderate-to-excellent inhibitory activity against ACE. In particular, compound 4i was found to be the most potent ACE inhibitor and was further studied for cardioprotective effects against isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Compound 4i improved the cardiac function and prevented cardiac injury induced by ISO in Sprague Dawley rats. The levels of oxidative stress and proinflammatory cytokines were also restored to near normal by 4i as compared with the ISO group. In the Western blot analysis, compound 4i prevented mitochondrial apoptosis after MI by downregulating the expression of cleaved caspase-3 and Bax, with the upregulation of Bcl-2, as compared with the ISO group.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 2631-72-3