1-(2-hydroxyethyl)-1H-indole-3-carbaldehyde

Base Information

• Chemical Name: 1-(2-hydroxyethyl)-1H-indole-3-carbaldehyde
• CAS No.: 161261-55-8
• Molecular Formula: C11H11NO2
• Molecular Weight: 0.00000
• Mol file: 161261-55-8.mol

Synonyms:

Chemical Property of 1-(2-hydroxyethyl)-1H-indole-3-carbaldehyde

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

98%min ^*data from raw suppliers

1-(2-Hydroxyethyl)-1H-indole-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-hydroxyethyl)-1H-indole-3-carbaldehyde

There total 8 articles about 1-(2-hydroxyethyl)-1H-indole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(3-formyl-1H-indol-1-yl)ethyl acetate → 1-(2-hydroxyethyl)-1H-indole-3-carbaldehyde (161261-55-8)

Guidance literature:

With sodium methylate; In methanol; for 0.166667h;

DOI:10.3390/ph13120469

Reference yield: 85.0%

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) + 2-bromoethanol (540-51-2) → 1-(2-hydroxyethyl)-1H-indole-3-carbaldehyde (161261-55-8)

Guidance literature:

Indole-3-carboxaldehyde; With potassium hydroxide; In acetonitrile; at 20 ℃; for 0.25h;

2-bromoethanol; In acetonitrile; for 0.25h;

Reference yield: 80.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(1H-indol-1-yl)ethanol (121459-15-2) → 1-(2-hydroxyethyl)-1H-indole-3-carbaldehyde (161261-55-8)

Guidance literature:

With sodium benzoate; lithium perchlorate; 4-chloro-aniline; In water; acetonitrile; at 20 ℃; for 18h; Electrolysis;

DOI:10.1021/acs.orglett.9b02433

upstream raw materials:

Indole-3-carboxaldehyde

2-bromoethanol

N,N,N,N,-tetramethylethylenediamine

2-(1H-indol-1-yl)ethanol

Refernces

• 1、 Yang, Liquan,Liu, Zhaoran,Li, Yujun,Lei, Ning,Shen, Yanling,Zheng, Ke. "Electrochemically Enabled C3-Formylation and -Acylation of Indoles with Aldehydes". supporting information. p. 7702 - 7707. Retrieved 2019/10/19.
• 2、 Zahran, Magdy A.,Afify, Hanan M.,Pedersen, Erik B.,Nielsen, Claus. "Synthesis of 1-Substituted Indole-3-carboxaldehydes Related to Acyclic Nucleosides and Their Condensed Pyrenyl Derivatives". . p. 101 - 114. Retrieved 2007/10/03.