AcetaMide, N-hydroxy-2-[[(4-Methoxyphenyl)sulfonyl](2-Methylpropyl)aMino]-

Base Information

• Chemical Name: AcetaMide, N-hydroxy-2-[[(4-Methoxyphenyl)sulfonyl](2-Methylpropyl)aMino]-
• CAS No.: 161314-17-6
• Molecular Formula: C13H20N2O5S
• Molecular Weight: 316.37
• Mol file: 161314-17-6.mol

Synonyms:

Chemical Property of AcetaMide, N-hydroxy-2-[[(4-Methoxyphenyl)sulfonyl](2-Methylpropyl)aMino]-

Chemical Property:

• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble15mg/mL, clear

Purity/Quality:

98%Min ^*data from raw suppliers

NNGH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: NNGH is a cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases (MMPs). It blocks the activity of MMP-8, -9, -12, -13, and -20 with Ki values of 9, 2.6, 4.3, 3.1, and 17 nM, respectively. It also inhibits MMP-1, -3, -7, and -10 with Ki values of 0.17, 0.13, 13, and 0.1 μM, respectively. It is commonly used to study the role of MMP-3 (stromelysin 1) in biological systems.
• Uses: MMP-3 Inhibitor II is a cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases (MMPs). It blocks the activity of MMP-8, -9, -12, -13, and -20 with Ki values of 9, 2.6, 4.3, 3.1, and 17 nM, respectively. It also inhibits MMP-1, -3, -7, and -10 with Ki values of 0.17, 0.13, 13, and 0.1 μM, respectively. It is commonly used to study the role of MMP-3 (stromelysin 1) in biological systems.[Cayman Chemical] NNGH acts as a matrix metalloproteinase (MMP) inhibitor affecting the degredation of all the components of the extracellular matrix. Thought to be crucial for agressive processes tumor metastasis and angiogenesis.

Technology Process of AcetaMide, N-hydroxy-2-[[(4-Methoxyphenyl)sulfonyl](2-Methylpropyl)aMino]-

There total 4 articles about AcetaMide, N-hydroxy-2-[[(4-Methoxyphenyl)sulfonyl](2-Methylpropyl)aMino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

ethyl 2-[[4-methoxybenzenesulfonyl](isobutyl)-amino]acetate (177702-12-4) → N-hydroxy-2-[isobutyl-(4-methoxybenzenesulfonyl)amino]acetamide (161314-17-6)

Guidance literature:

With hydroxylamine hydrochloride; sodium methylate; In methanol; at 20 ℃;

DOI:10.1021/jm900648x

Reference yield:

4-methoxy-phenyl-sulphonyl chloride (98-68-0) → N-hydroxy-2-[isobutyl-(4-methoxybenzenesulfonyl)amino]acetamide (161314-17-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CHCl₃ / 1.) RT, 1 h, 2.) reflux, 1 h

2: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, RT, overnight

3: HONH₂*HCl, NaOMe / methanol / Ambient temperature

With hydroxylamine hydrochloride; sodium methylate; sodium hydride; triethylamine; In methanol; chloroform;

DOI:10.1021/jm960871c

Reference yield:

N-isobutyl-4-methoxybenzenesulfonamide (172738-60-2) → N-hydroxy-2-[isobutyl-(4-methoxybenzenesulfonyl)amino]acetamide (161314-17-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, RT, overnight

2: HONH₂*HCl, NaOMe / methanol / Ambient temperature

With hydroxylamine hydrochloride; sodium methylate; sodium hydride; In methanol;

DOI:10.1021/jm960871c

upstream raw materials:

ethyl 2-[[4-methoxybenzenesulfonyl](isobutyl)-amino]acetate

4-methoxy-phenyl-sulphonyl chloride

N-isobutyl-4-methoxybenzenesulfonamide