Cyclohexane, 1-(1,1-dimethylethyl)-4-iodo-, trans-

Base Information

• Chemical Name: Cyclohexane, 1-(1,1-dimethylethyl)-4-iodo-, trans-
• CAS No.: 16133-42-9
• Molecular Formula: C10H19I
• Molecular Weight: 266.165
• Mol file: 16133-42-9.mol

Synonyms:

Chemical Property of Cyclohexane, 1-(1,1-dimethylethyl)-4-iodo-, trans-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexane, 1-(1,1-dimethylethyl)-4-iodo-, trans-

There total 7 articles about Cyclohexane, 1-(1,1-dimethylethyl)-4-iodo-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

C19H23NO4 → trans-1-(tert-butyl)-4-iodocyclohexane (16133-42-9) + cis-1-(tert-butyl)-4-iodocyclohexane (16133-41-8)

Guidance literature:

With triphenylphosphine; lithium iodide; In acetone; at 28 ℃; for 24h; diastereoselective reaction; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.0c03173

Reference yield: 20.0%

cis-4-tert-butyl-1-cyclohexanol (937-05-3) → trans-1-(tert-butyl)-4-iodocyclohexane (16133-42-9) + cis-1-(tert-butyl)-4-iodocyclohexane (16133-41-8) + 4-tert-butylcylohexene (2228-98-0)

Guidance literature:

With N,N'-dicyclohexyl-N-methylcarbodiimidium iodide; In tetrahydrofuran; at 25 ℃;

DOI:10.1016/S0040-4020(01)86959-3

Reference yield:

cis-4-tert-butyl-1-cyclohexanol (937-05-3) → trans-1-(tert-butyl)-4-iodocyclohexane (16133-42-9) + cis-1-(tert-butyl)-4-iodocyclohexane (16133-41-8)

Guidance literature:

With 1-methyl-1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 0 ℃; for 15h; Overall yield = 20 %; Overall yield = 3 g; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201204076

upstream raw materials:

cis-4-tert-butylcyclohexyl tosylate

cis-4-tert-butyl-1-cyclohexanol

4-(1,1-dimethylethyl)-cyclohexanol

trans-4-tert-butylcyclohexanol

Downstream raw materials:

1-tert-butyl-4-deuterio-cyclohexane