(2R,3R)-2-Hydroxy-3-[benzyl[(R)-alpha-methylbenzyl]amino]butyric acid tert-butyl ester

Base Information

Chemical Name:(2R,3R)-2-Hydroxy-3-[benzyl[(R)-alpha-methylbenzyl]amino]butyric acid tert-butyl ester
CAS No.:161453-10-7
Molecular Formula:C23H31NO3
Molecular Weight:369.504
Hs Code.:
DSSTox Substance ID:DTXSID101123543
Nikkaji Number:J603.529I
Mol file:161453-10-7.mol

Synonyms:DTXSID101123543;(2R,3R)-2-Hydroxy-3-[benzyl[(R)-alpha-methylbenzyl]amino]butyric acid tert-butyl ester;1,1-Dimethylethyl (2R,3R)-2-hydroxy-3-[[(1R)-1-phenylethyl](phenylmethyl)amino]butanoate;161453-10-7

Suppliers and Price of (2R,3R)-2-Hydroxy-3-[benzyl[(R)-alpha-methylbenzyl]amino]butyric acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2R,3R)-2-Hydroxy-3-[benzyl[(R)-alpha-methylbenzyl]amino]butyric acid tert-butyl ester

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:369.23039385
Heavy Atom Count:27
Complexity:447

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC=CC=C1)N(CC2=CC=CC=C2)C(C)C(C(=O)OC(C)(C)C)O
Isomeric SMILES:C[C@H](C1=CC=CC=C1)N(CC2=CC=CC=C2)[C@H](C)[C@H](C(=O)OC(C)(C)C)O

Technology Process of (2R,3R)-2-Hydroxy-3-[benzyl[(R)-alpha-methylbenzyl]amino]butyric acid tert-butyl ester

There total 4 articles about (2R,3R)-2-Hydroxy-3-[benzyl[(R)-alpha-methylbenzyl]amino]butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 79218-15-8
tert-butyl (E)-crotonate

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 161453-10-7
tert-butyl (2R,3R,αR)-3--2-hydroxybutyrate

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

tert-butyl (E)-crotonate; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

With (1R)-(?)-(10-camphorsulfonyl)oxaziridine; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 14h; diastereoselective reaction;
DOI:10.1016/j.tet.2014.06.057

Reference yield: 58.0%

: 3246-27-3
tert-butyl crotonate

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 161453-10-7
tert-butyl (2R,3R,αR)-3--2-hydroxybutyrate

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

tert-butyl crotonate; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

With (1R)-(?)-(10-camphorsulfonyl)oxaziridine; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 12h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2012.03.045

Reference yield:

: 134430-98-1
tert-butyl (3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)butanoate

: 161453-10-7
tert-butyl (2R,3R,αR)-3--2-hydroxybutyrate

Guidance literature:: With [4aS-(4a,7,8aR)]-tetrahydro-9,9-dimethyl-4H-4A,7-methanooxazirino[3,2-i][2,1]benzisothiazole 3,3-dioxide; In tetrahydrofuran; at -78 - 20 ℃; for 19h;
DOI:10.1021/ja2011109