2-Hexanone, 5-methyl-4-phenyl-, (4R)-

Base Information

• Chemical Name: 2-Hexanone, 5-methyl-4-phenyl-, (4R)-
• CAS No.: 162239-77-2
• Molecular Formula: C13H18O
• Molecular Weight: 190.285
• Mol file: 162239-77-2.mol

Synonyms:

Chemical Property of 2-Hexanone, 5-methyl-4-phenyl-, (4R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Hexanone, 5-methyl-4-phenyl-, (4R)-

There total 18 articles about 2-Hexanone, 5-methyl-4-phenyl-, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-methyl-3-hexene-2-one (5166-53-0) + phenylboronic acid (98-80-6) → (R)-5-methyl-4-phenyl-hexan-2-one (162239-77-2)

Guidance literature:

With potassium hydroxide; chlorobis(ethylene)rhodium(I) dimer; (Ra)-(6,6'-dimethoxybiphenyl-2,2'-diyl)bis[bis(3,4,5-trifluorophenyl)phosphine]; water; In toluene; at 20 ℃; for 0.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol900719z

Reference yield: 94.0%

[2-(hydroxymethyl)phenyl]dimethyl(phenyl)silane (853955-69-8) + (E)-4-isopropylbut-3-en-2-one (1669-43-8,5166-53-0,1821-29-0) → (R)-5-methyl-4-phenyl-hexan-2-one (162239-77-2)

Guidance literature:

With potassium hydroxide; (1R,4R)-2,5-dibenzylbicyclo[2.2.2]octa-2,5-diene; bis(ethylene)rhodium(I) chloride dimer; In tetrahydrofuran; at 40 ℃; for 5h;

DOI:10.1021/ja071969r

Reference yield: 91.0%

(E)-4-isopropylbut-3-en-2-one (1669-43-8,5166-53-0,1821-29-0) + phenylboronic acid (98-80-6) → (R)-5-methyl-4-phenyl-hexan-2-one (162239-77-2)

Guidance literature:

With potassium hydroxide; di(norbornadiene)rhodium(I) tetrafluoroborate; In 1,4-dioxane; water; at 40 ℃; for 2h;

DOI:10.1002/anie.200702513

upstream raw materials:

(E)-4-isopropylbut-3-en-2-one

phenylboronic acid

phenylzinc chloride

triphenylbismuthane