3-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID HYDRAZIDE

Base Information

• Chemical Name: 3-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID HYDRAZIDE
• CAS No.: 62524-21-4
• Molecular Formula: C9H7ClN2OS
• Molecular Weight: 226.686
• Hs Code.: 29349990
• Mol file: 62524-21-4.mol

Synonyms:3-Chloro-benzo[b]thiophene-2-carboxylic acid hydrazide;

Chemical Property of 3-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID HYDRAZIDE

Chemical Property:

• Melting Point: 181 °C
• Refractive Index: 1.714
• PSA: 83.36000
• Density: 1.486 g/cm³
• LogP: 3.24940
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-1-benzothiophene-2-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID HYDRAZIDE

There total 4 articles about 3-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-chlorobenzo[b]thiophen-2-carbonyl chloride (21815-91-8) → 3-chloro-2-hydrazinocarbonylbenzothiophene (62524-21-4)

Guidance literature:

With hydrazine hydrate;

DOI:10.1080/10426500903241713

Reference yield: 94.0%

3-chlorobenzo[b]thiophene-2-carboxylic acid methyl ester (21211-07-4) → 3-chloro-2-hydrazinocarbonylbenzothiophene (62524-21-4)

Guidance literature:

With hydrazine hydrate; In methanol; for 1h; Heating;

DOI:10.1002/ardp.19923250213

Reference yield:

Cinnamic acid (621-82-9) → 3-chloro-2-hydrazinocarbonylbenzothiophene (62524-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; chlorobenzene

2: hydrazine hydrate / ethanol / 4 h / Reflux

With thionyl chloride; hydrazine hydrate; chlorobenzene; In ethanol;

upstream raw materials:

3-chlorobenzo[b]thiophene-2-carboxylic acid methyl ester

3-chlorobenzo[b]thiophen-2-carbonyl chloride

Cinnamic acid

(E)-3-phenylacrylic acid

Downstream raw materials:

3-Chloro-benzo[b]thiophene-2-carboxylic acid [1-thiophen-2-yl-meth-(E)-ylidene]-hydrazide

3-chloro-2-(2-oxo-3H-1,3,4-oxadiazole-5-yl)-benzo(b)thiophene

3-Chloro-benzo[b]thiophene-2-carboxylic acid [1-(4-bromo-phenyl)-eth-(E)-ylidene]-hydrazide

3-Chloro-benzo[b]thiophene-2-carboxylic acid [1-(2-amino-phenyl)-eth-(E)-ylidene]-hydrazide