21211-07-4

Usage

Chemical Properties

White solid

InChI:InChI=1/C10H7ClO2S/c1-13-10(12)9-8(11)6-4-2-3-5-7(6)14-9/h2-5H,1H3

Upstream product

• 67-56-1 methanol 
• 21815-91-8 3-chlorobenzo[b]thiophen-2-carbonyl chloride 
• 621-82-9 Cinnamic acid 
• 19713-73-6 methyl (2Z)-3-phenylprop-2-enoate 

Downstream Products

• 22913-24-2 methyl benzo[b]thiophene-2-carboxylate 
• 881033-63-2 1-Carboxymethoxy-3,8-dithia-cyclopenta[a]indene-2-carboxylic acid 
• 78620-31-2 3-chloro-2-(2-oxo-3H-1,3,4-oxadiazole-5-yl)-benzo(b)thiophene 
• 14006-54-3 3-chloro-1-benzothiophen-2-carbaldehyde 
• 124168-55-4 (3-chloro-benzo[b]thiophen-2-yl)-methanol 
• 59812-38-3 (3-chloro-1-benzothiophen-2-yl)(phenyl)methanone 
• 29491-86-9 3-phenylbenzo[b]thiophene-2-carboxylic acid 
• 1213779-82-8 methyl 3-(4-(trifluoromethyl)phenyl)benzo[b]thiophene-2-carboxylate 
• 1213779-81-7 methyl 3-(4-methoxyphenyl)benzo[b]thiophene-2-carboxylate 
• 162154-06-5 3-(4-tolyl)-2-methoxycarbonylbenzo[b]thiophene 
• 1213779-93-1 C₁₈H₁₆O₄S₂ 
• 140181-93-7 3-Chloro-benzo[b]thiophene-2-carboxylic acid [3-(4-methoxy-phenyl)-4-(4-nitro-phenyl)-3H-thiazol-(2Z)-ylidene]-hydrazide 
• 140181-94-8 3-Chloro-benzo[b]thiophene-2-carboxylic acid [4-biphenyl-4-yl-3-(4-methoxy-phenyl)-3H-thiazol-(2Z)-ylidene]-hydrazide 
• 140181-87-9 3-Chloro-benzo[b]thiophene-2-carboxylic acid [3-(4-chloro-phenyl)-4-(4-nitro-phenyl)-3H-thiazol-(2Z)-ylidene]-hydrazide 

Relevant academic research and scientific papers

Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives

Benzo[b]thiophene molecules are found to be important tools in synthetic medicinal chemistry. They are of current interest due to their wide spectrum of pharmacological properties. In view of the biological activities of benzo[b]thiophene containing molecules, in this present research work, we propose the synthesis of some new benzo[b]thiophene derivatives such as thiadiazoles, oxadiazoles, pyrazolin & diaryl pyrazoles starting from 3-chlorobenzo[b]thiophene-2-carboxyl chloride. These newly synthesized compounds were characterized by elemental analyses, I.R, NMR and Mass spectral studies. Some of the selected compounds were screened for their antibacterial, antifungal and anti-inflammatory studies. Many of the molecules were found to be potent.

Synthesis and antitumour activity of new derivatives of flavone-8- acetic acid (FAA). Part 31): 2-Heteroaryl derivatives

A range of 14 derivatives of flavone-8-acetic acid (FAA) with a heterocyclic substituent in place of the 2-phenyl group have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. Some of the compounds, notably 2c,d and s, showed significant in vivo activity and these require further studies in order to evaluate their potential for development.

Benzo[b]thiophenes, Part I: Synthesis and antimicrobial activity of benzo[b]thienyl-1,3,4-oxadiazole, -1,2,4-triazoline, and -thiazoline derivatives

Four new series of benzo[b]thiophene derivatives bearing various thiosemicarbazide, 1,3,4-oxadiazole, 1,2,4-triazoline, and thiazoline moieties have been synthesized and evaluated for antimicrobial activity.

Sythesis of substituted Benzothiophenes

Cyclization of the cinnamic acids 1a-t and their derivatives 1u,1v, and 1w with thionyl chloride affords the benzothiophenes 2a-t and 2v,w, respectively. 2a and 2v,w have been also prepared in an independent way from the corresponding alkynes and disulfur dichloride.