Propanamide, N-[6-(hydroxymethyl)-2-pyridinyl]-2,2-dimethyl-

Base Information

• Chemical Name: Propanamide, N-[6-(hydroxymethyl)-2-pyridinyl]-2,2-dimethyl-
• CAS No.: 165685-25-6
• Molecular Formula: C11H16N2O2
• Molecular Weight: 208.25700
• Mol file: 165685-25-6.mol

Synonyms:N-[6-(1-hydroxymethyl)pyridin-2-yl]-2,2-dimethylpropanamide;N-pivaloyl-2-amino-6-hydroxymethylpyridine;N-(6-hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide;2-(N-pivaloylamino)-6-hydroxymethylpyridine;Propanamide,N-[6-(hydroxymethyl)-2-pyridinyl]-2,2-dimethyl;

Chemical Property of Propanamide, N-[6-(hydroxymethyl)-2-pyridinyl]-2,2-dimethyl-

Chemical Property:

• Melting Point: 117-120 °C
• Boiling Point: 413.0±35.0 °C(Predicted)
• PSA: 65.71000
• Density: 1.162±0.06 g/cm3(Predicted)
• LogP: 2.20800

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanamide, N-[6-(hydroxymethyl)-2-pyridinyl]-2,2-dimethyl-

There total 1 articles about Propanamide, N-[6-(hydroxymethyl)-2-pyridinyl]-2,2-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

N-(6-(bromomethyl)-2-pyridyl)pivalamide (111477-43-1) → (6-Amino-pyridin-2-yl)-methanol (79651-64-2) + 2-(N-pivaloylamino)-6-hydroxymethylpyridine (165685-25-6)

Guidance literature:

With sulfuric acid; for 1h; Heating;

DOI:10.1002/jhet.5570320250

Reference yield: 96.0%

2-(N-pivaloylamino)-6-hydroxymethylpyridine (165685-25-6) → (6-Amino-pyridin-2-yl)-methanol (79651-64-2)

Guidance literature:

2-(N-pivaloylamino)-6-hydroxymethylpyridine; With hydrogenchloride; water; In 1,4-dioxane; at 90 ℃; for 14h;

With sodium hydroxide; In 1,4-dioxane; water; pH=~ 8;

Reference yield:

4-hydroxybenzotrifluoride (402-45-9) + 2-(N-pivaloylamino)-6-hydroxymethylpyridine (165685-25-6) → 2,2-dimethyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-propionamide (882016-17-3)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 20 ℃; for 2h;

upstream raw materials:

N-(6-(bromomethyl)-2-pyridyl)pivalamide

Downstream raw materials:

2,2-dimethyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-propionamide

(6-Amino-pyridin-2-yl)-methanol