4-(4-Fluorophenyl)-1-(4-piperidinyl)-5-(2-amino-4-pyrimidinyl)-imidazole

Base Information

Chemical Name:4-(4-Fluorophenyl)-1-(4-piperidinyl)-5-(2-amino-4-pyrimidinyl)-imidazole
CAS No.:165806-53-1
Molecular Formula:C18H19FN6
Molecular Weight:338.38200
Hs Code.:2933990090
European Community (EC) Number:827-712-1
UNII:MX95H97VRG
Nikkaji Number:J1.634.061H
Wikidata:Q27088707
Pharos Ligand ID:BPLYL9DXRMNF
Metabolomics Workbench ID:148799
ChEMBL ID:CHEMBL274064
Mol file:165806-53-1.mol

Synonyms:5-(2-amino-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole;SB 220025;SB-220025;SB220025

Suppliers and Price of 4-(4-Fluorophenyl)-1-(4-piperidinyl)-5-(2-amino-4-pyrimidinyl)-imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
SB 220025 95.00%
5MG
$ 505.57

Total 21 raw suppliers

Chemical Property of 4-(4-Fluorophenyl)-1-(4-piperidinyl)-5-(2-amino-4-pyrimidinyl)-imidazole

Chemical Property:

Boiling Point:611.9±65.0 °C(Predicted)
PKA:9.92±0.10(Predicted)
PSA：81.65000
Density:1.42±0.1 g/cm3(Predicted)
LogP:3.56290
Storage Temp.:-20°C
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:338.16552279
Heavy Atom Count:25
Complexity:424

Purity/Quality:

≥95% ^*data from raw suppliers

SB 220025 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC1N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F

Technology Process of 4-(4-Fluorophenyl)-1-(4-piperidinyl)-5-(2-amino-4-pyrimidinyl)-imidazole

There total 6 articles about 4-(4-Fluorophenyl)-1-(4-piperidinyl)-5-(2-amino-4-pyrimidinyl)-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: benzyl (4-(1-(1-benzylpiperidin-4-yl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyrimidin-2-yl)carbamate

: 165806-53-1
SB220025

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In methanol; at 50 ℃;

Reference yield:

: guanidine·HCl

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 67-63-0,8013-70-5
isopropyl alcohol

: 186315-19-5
1-(1-Ethoxycarbonyl-4-piperidinyl)-4-(4-fluorophenyl)-5-acetylimidazole

: 165806-53-1
SB220025

Guidance literature:: With potassium hydroxide; potassium carbonate; In ethanol; water; toluene;

Reference yield:

: 50541-93-0
4-amino-1-benzylpiperidine

: 165806-53-1
SB220025

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; hydrogenchloride / water; tetrahydrofuran / 15 °C / Cooling with ice

1.2: 3 h / 20 °C

2.1: potassium carbonate / dichloromethane; water / 20 - 30 °C

3.1: palladium 10% on activated carbon; ammonium formate / methanol / 50 °C

With hydrogenchloride; palladium 10% on activated carbon; ammonium formate; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;