2-Propyn-1-one, 3-(1-hydroxycyclohexyl)-1-phenyl-

Base Information

Chemical Name:2-Propyn-1-one, 3-(1-hydroxycyclohexyl)-1-phenyl-
CAS No.:16616-45-8
Molecular Formula:C15H16O2
Molecular Weight:228.291
Hs Code.:
DSSTox Substance ID:DTXSID40481632
Nikkaji Number:J2.945.366G
Wikidata:Q82317143
Mol file:16616-45-8.mol

Synonyms:16616-45-8;2-Propyn-1-one, 3-(1-hydroxycyclohexyl)-1-phenyl-;DTXSID40481632

Suppliers and Price of 2-Propyn-1-one, 3-(1-hydroxycyclohexyl)-1-phenyl-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propyn-1-one, 3-(1-hydroxycyclohexyl)-1-phenyl-

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:228.115029749
Heavy Atom Count:17
Complexity:332

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCC(CC1)(C#CC(=O)C2=CC=CC=C2)O

Technology Process of 2-Propyn-1-one, 3-(1-hydroxycyclohexyl)-1-phenyl-

There total 6 articles about 2-Propyn-1-one, 3-(1-hydroxycyclohexyl)-1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-88-4
benzoyl chloride

: 78-27-3
1-Ethynylcyclohexan-1-ol

: 16616-45-8
3-(1-hydroxycyclohexyl)-1-phenylprop-2-yn-1-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.666667h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.8b02077

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 16616-45-8
3-(1-hydroxycyclohexyl)-1-phenylprop-2-yn-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 4 h / 20 °C / Cooling with ice; Schlenk technique; Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 0.67 h / 20 °C / Inert atmosphere; Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran;
DOI:10.1021/acs.orglett.8b02077

Reference yield:

: 1357268-87-1
1-phenyl-3-(1-((tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl)prop-2-yn-1-ol

: 16616-45-8
3-(1-hydroxycyclohexyl)-1-phenylprop-2-yn-1-one

Guidance literature:: 1-phenyl-3-(1-((tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl)prop-2-yn-1-ol; With manganese(IV) oxide; In dichloromethane; at 0 - 20 ℃;

With pyridinium p-toluenesulfonate; In ethanol; at 50 ℃;
DOI:10.1016/j.tet.2011.08.084