Piperidine, 2,6-dimethyl-1-nitroso-, cis-

Base Information

• Chemical Name: Piperidine, 2,6-dimethyl-1-nitroso-, cis-
• CAS No.: 16642-61-8
• Molecular Formula: C₇H₁₄N₂O
• Molecular Weight: 142.201
• Mol file: 16642-61-8.mol

Synonyms:cis-2,6-Dimethyl-1-nitrosopiperidin;N-Nitroso-cis-2,6-dimethyl-piperidin;cis-2,6-dimethyl-1-nitrosopiperidine;cis-syn-2,6-Dimethyl-N-nitrosopiperidin;2r,6c-Dimethyl-1-nitroso-piperidin;2r,6c-dimethyl-1-nitroso-piperidine;Piperidine,2,6-dimethyl-1-nitroso-,cis;1-Nitroso-cis-2,6-dimethyl-piperidin;

Chemical Property of Piperidine, 2,6-dimethyl-1-nitroso-, cis-

Chemical Property:

• PSA: 32.67000
• LogP: 1.86860

Purity/Quality:

99% ^*data from raw suppliers

(2R,6S)-rel-2,6-Dimethyl-1-nitrosopiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2R,6S)-rel-2,6-Dimethyl-1-nitrosopiperidine is an intermediate in the synthesis of N-nitrosamines as diuretics.

Technology Process of Piperidine, 2,6-dimethyl-1-nitroso-, cis-

There total 3 articles about Piperidine, 2,6-dimethyl-1-nitroso-, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,6S)-2,6-dimethylpiperidine (766-17-6,1218906-26-3) → cis-2,6-dimethyl-1-nitrosopiperidine (16642-61-8)

Guidance literature:

With hydrogenchloride; sodium nitrite;

DOI:10.1021/ja01620a040

Reference yield:

2,6-dimethylpyridine (108-48-5) → cis-2,6-dimethyl-1-nitrosopiperidine (16642-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: rhodium/ aluminium oxide; acetic acid / 60 °C / Hydrogenation

2: aqueous hydrochloric acid; sodium nitrite

With hydrogenchloride; Rh/Al₂O₃; acetic acid; sodium nitrite;

DOI:10.1021/ja01620a040

Reference yield:

→ cis-2,6-dimethyl-1-nitrosopiperidine (16642-61-8)

Guidance literature:

DOI:10.1016/0022-2852(67)90005-7

upstream raw materials:

(2R,6S)-2,6-dimethylpiperidine

2,6-dimethylpyridine

Downstream raw materials:

2,6-cis-dimethyl-1-amino-piperidine