cis-2,6-Dimethylpiperidine

Base Information

• Chemical Name: cis-2,6-Dimethylpiperidine
• CAS No.: 766-17-6
• Molecular Formula: C₇H₁₅N
• Molecular Weight: 113.203
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID30859422
• Nikkaji Number: J853.999E
• ChEMBL ID: CHEMBL1517793
• Mol file: 766-17-6.mol

Synonyms:cis-2,6-Dimethylpiperidine;766-17-6;(2R,6S)-2,6-dimethylpiperidine;cis-Hexahydro-2,6-lutidine;cis-2,6-dimethyl-piperidine;Piperidin, 2e,6e-dimethyl;NCGC00016653-01;CAS-5072-45-7;cis-Lupetidine;MFCD00066304;2,6-Lupetidine, cis-;Prestwick0_000666;Prestwick1_000666;Prestwick2_000666;Prestwick3_000666;Piperidine, 2,6-dimethyl-, (2R,6S)-rel-;cis-2,6-dimethyl piperidine;SCHEMBL83612;BSPBio_000731;SPBio_002652;BPBio1_000805;CHEMBL1517793;DTXSID30859422;(2S,6R)-2,6-dimethylpiperidine;cis-2,6-Dimethylpiperidine, 98%;Piperidine, 2,6-dimethyl-, cis-;(2R,6S)-2,6-Dimethylpiperidine;cis-2,6-Lupetidine;meso-2,6-Lupetidine;(2S,6R)-2,6-dimethyl-piperidine;AKOS006349672;cis-2,6-Dimethylpiperidine 766-17-6;NCGC00016653-02;AS-81925;piperidine, 2,6-dimethyl-, (2R,6S)-;D1198;EN300-96678;cis-2,6-Dimethylpiperidine, >=97.0% (GC);E79217;A838770;F8889-9209;Z1203730759

Chemical Property of cis-2,6-Dimethylpiperidine

Chemical Property:

• Appearance/Colour: Colorless liquid
• Melting Point: <-20 °C
• Refractive Index: n20/D 1.4394(lit.)
• Boiling Point: 127.1 °C at 760 mmHg
• PKA: pK1:11.07(+1) (25°C)
• Flash Point: 11.7 °C
• PSA: 12.03000
• Density: 0.794 g/cm³
• LogP: 1.86570
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 113.120449483
• Heavy Atom Count: 8
• Complexity: 62.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

cis-2,6-Lupetidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xi
• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Cyclic
• Canonical SMILES: CC1CCCC(N1)C
• Isomeric SMILES: C[C@@H]1CCC[C@@H](N1)C

Technology Process of cis-2,6-Dimethylpiperidine

There total 4 articles about cis-2,6-Dimethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Li(cis-2,6-dimethylpiperidine(-1H)) (38227-84-8,84602-07-3,84602-08-4) + diisopropylamine (108-18-9) → (2R,6S)-2,6-dimethylpiperidine (766-17-6,1218906-26-3) + lithium diisopropyl amide (4111-54-0)

Guidance literature:

In tetrahydrofuran; at -65 ℃; Thermodynamic data; Rate constant; ΔG(excit.);

DOI:10.1016/S0040-4039(00)88702-X

Reference yield:

→ succinic acid anhydride (108-30-5) + (2R,6S)-2,6-dimethylpiperidine (766-17-6,1218906-26-3)

Guidance literature:

Reference yield:

→ (R)-2,6-Dimethyl-piperidine (504-03-0,766-17-6,10066-29-2,14231-78-8,40249-88-5,40250-84-8)

Guidance literature:

aus R-(-)-1-Methylhexylamin n.bekannten Methoden;

DOI:10.1016/0040-4020(78)88383-5

upstream raw materials:

Li(cis-2,6-dimethylpiperidine(-1H))

diisopropylamine

cis-1,2,6-trimethylpiperidine

Downstream raw materials:

cis-2,6-dimethyl-α,α-diphenyl-1-piperidinebutanenitrile

2r,6c-dimethyl-piperidine-1-carboxamidine

(2r,6c-dimethyl-piperidino)-acetic acid-(2,4,6-trimethyl-anilide)

2r,6c-dimethyl-1-veratryl-piperidine

Refernces

• 1、 -. "Diesters of carbonic acid endowed with antiviral and anti-inflammatory activity". . . Retrieved 2008/06/13.