Bicyclo[2.2.1]heptane-2-carboxylic acid, methyl ester, endo-

Base Information

• Chemical Name: Bicyclo[2.2.1]heptane-2-carboxylic acid, methyl ester, endo-
• CAS No.: 16646-41-6
• Molecular Formula: C9H14O2
• Molecular Weight: 154.209
• Mol file: 16646-41-6.mol

Synonyms:endo-2-(Carbomethoxy)bicyclo<2.2.1>heptane;(+-)-Norbornan-carbonsaeure-(2endo)-methylester;(1R,2S,4S)-Bicyclo[2.2.1]heptane-2-carboxylic acid methyl ester;(+-)-Norbornan-2endo-carbonsaeure-methylester;endo-2-Methoxycarbonyl-bicyclo<2,2,1>heptan;endo-2-carboxymethyl-bicyclo(2.2.1)heptane;(+-)-norbornane-2endo-carboxylic acid methyl ester;

Chemical Property of Bicyclo[2.2.1]heptane-2-carboxylic acid, methyl ester, endo-

Chemical Property:

• Boiling Point: 67 - 68 °C (8 mmHg)
• PSA: 26.30000
• LogP: 1.59560

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bicyclo[2.2.1]heptane-2-carboxylic acid, methyl ester, endo-

There total 10 articles about Bicyclo[2.2.1]heptane-2-carboxylic acid, methyl ester, endo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

endo-norbornenecarboxylic acid (120-74-1,934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7) → (+/-)-di-tert-butyl 4β,11β-bis(benzyloxycarbonyl)-16-oxa-(1α,2β,3α,6α,7β,8α,9β,10α,13α,14β)-hexacyclo[6.6.1.14,6.110,13.02,7.09,14]heptadeca-1,8-dicarboxylate + endo-2-methyl-2-(carbomethoxy)bicyclo<2.2.1>heptane (61109-88-4) + methyl bicyclo<2.2.1>heptane-2-endo-carboxylate (16646-41-6) + exo-2-methyl-2-(carbomethoxy)bicyclo<2.2.1>heptane (28738-72-9)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 11.1 - 17.9 ℃; for 1.23333h; Product distribution / selectivity;

Reference yield:

endo-norbornenecarboxylic acid (120-74-1,934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7) → (+/-)-di-tert-butyl 4β,11β-bis(benzyloxycarbonyl)-16-oxa-(1α,2β,3α,6α,7β,8α,9β,10α,13α,14β)-hexacyclo[6.6.1.14,6.110,13.02,7.09,14]heptadeca-1,8-dicarboxylate + endo-2-methyl-2-(carbomethoxy)bicyclo<2.2.1>heptane (61109-88-4) + methyl bicyclo<2.2.1>heptane-2-endo-carboxylate (16646-41-6) + exo-2-methyl-2-(carbomethoxy)bicyclo<2.2.1>heptane (28738-72-9) + exo-2-ethyl-2-carboxybicyclo<2.2.1>heptane (73873-42-4)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 11.1 - 17.9 ℃; for 1.23333h; Product distribution / selectivity;

Reference yield:

endo-norbornenecarboxylic acid (120-74-1,934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7) → (+/-)-di-tert-butyl 4β,11β-bis(benzyloxycarbonyl)-16-oxa-(1α,2β,3α,6α,7β,8α,9β,10α,13α,14β)-hexacyclo[6.6.1.14,6.110,13.02,7.09,14]heptadeca-1,8-dicarboxylate + endo-2-methyl-2-(carbomethoxy)bicyclo<2.2.1>heptane (61109-88-4) + methyl bicyclo<2.2.1>heptane-2-endo-carboxylate (16646-41-6) + exo-2-methyl-2-(carbomethoxy)bicyclo<2.2.1>heptane (28738-72-9) + exo-2-ethyl-2-carboxybicyclo<2.2.1>heptane (73873-42-4) + endo-2-ethyl-2-carboxybicyclo<2.2.1>heptane (73873-44-6)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 11.1 - 17.9 ℃; for 1.23333h; Product distribution / selectivity;

upstream raw materials:

diazomethane

carbon dioxide

exo-2-chloronorbornane

endo-2-chloronorbornane

Downstream raw materials:

exo-bicyclo[2.2.1]heptane-2-carboxamide

exo-2-norbornanecarbonyl chloride

2-isopropylidenebicyclo<2.2.1>heptane